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Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

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ClinicalTrials.gov Identifier: NCT01779622
Recruitment Status : Completed
First Posted : January 30, 2013
Last Update Posted : September 30, 2014
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers

Condition or disease Intervention/treatment
Healthy Volunteers Recruited From the General Population Other: Mixed meal

Detailed Description:
A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin
Study Start Date : June 2013
Primary Completion Date : January 2014
Study Completion Date : June 2014
Arms and Interventions

Arm Intervention/treatment
Experimental: 1
Healthy volunteers are ingesting a mixed meal either rapidly or slowly
Other: Mixed meal
Ingestion of mixed meal


Outcome Measures

Primary Outcome Measures :
  1. Area under the curve for insulin [ Time Frame: 300 min ]

Secondary Outcome Measures :
  1. Area under the curve for glucose-dependent insuinotropic polypeptide [ Time Frame: 300 min ]
  2. Area under the curve for glucagon-like peptide-1 [ Time Frame: 300 min ]

Other Outcome Measures:
  1. Area under the curve for glucagon [ Time Frame: 300 min ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects

Exclusion Criteria:

  • Diabetes Liver disease Kidney disease Thyroid disease
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01779622


Locations
Sweden
Department of Clinical Sciences, Lund University
Lund, Sweden, 22184
Sponsors and Collaborators
Lund University
More Information

Additional Information:
Responsible Party: Bo Ahren, Professor, Lund University
ClinicalTrials.gov Identifier: NCT01779622     History of Changes
Other Study ID Numbers: 17
2013-000449-38 ( EudraCT Number )
First Posted: January 30, 2013    Key Record Dates
Last Update Posted: September 30, 2014
Last Verified: September 2014

Keywords provided by Bo Ahren, Lund University:
mixed meal¨
insulin
glucagon
GIP
GLP-1

Additional relevant MeSH terms:
Incretins
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs