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Oxygen Level and Safe Emergence From Anesthesia

This study has been completed.
Information provided by (Responsible Party):
Lennart Edmark, Landstinget Västmanland Identifier:
First received: January 28, 2013
Last updated: June 24, 2013
Last verified: June 2013
Using a protective ventilation strategy during general anesthesia from pre-oxygenation to emergence and selecting patients without risk of a difficult airway or intubation, a lower fraction of inspiratory oxygen (FIO2) can be used during extubation. This might reduce the postoperative area of atelectasis without desaturations becoming more common.

Condition Intervention
Focus of Study is Postoperative Pulmonary Atelectacis Procedure: 30% oxygen Procedure: 100% oxygen

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Prevention
Official Title: Emergence From General Anesthesia With Laryngeal Mask Airway and Increased End-expiratory Pressure Using 30% Oxygen is as Safe as With 100% Oxygen But Reduces the Area of Post Operative Atelectasis.

Resource links provided by NLM:

Further study details as provided by Lennart Edmark, Landstinget Västmanland:

Primary Outcome Measures:
  • Area of atelectasis [ Time Frame: 30 minutes ]
    The area of atelectasis is investigated by computed tomography of the lungs postoperatively

Secondary Outcome Measures:
  • Peripheral oxygen saturation (SpO2) [ Time Frame: 3 hours ]
    SpO2 is continuously assessed postoperatively.

Enrollment: 59
Study Start Date: February 2013
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 100% oxygen during extubation
In this arm the intervention will consist of 100 % oxygen.
Procedure: 100% oxygen
Experimental: 30% oxygen during extubation
In this arm the intervention will consist of 30 % oxygen.
Procedure: 30% oxygen


Ages Eligible for Study:   30 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • No sign of difficult airway or intubation
  • Day case surgery in total intravenous anesthesia with laryngeal mask airway without adding regional anesthesia of plexus brachialis or muscle relaxant.
  • Body mass index less than 35.
  • American Society of Anesthesiologists physical status (ASA) class I-III

Exclusion Criteria:

  • Body mass index 35 or higher
  • Increased risk of aspiration
  • Obstructive sleep apnea syndrome
  • Procedures during surgery making a former easy airway a difficult airway
  • Need for opioids after extubation
  • Hypothermia
  Contacts and Locations
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Please refer to this study by its identifier: NCT01779076

Västmanlands sjukhus Köping
Köping, Västmanland, Sweden, 731 81
Sponsors and Collaborators
Landstinget Västmanland
Principal Investigator: Mats Enlund, M.D., Ph.D. Landstinget i Värmland
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Lennart Edmark, M.D., Landstinget Västmanland Identifier: NCT01779076     History of Changes
Other Study ID Numbers: Dnr 2012 / 539
Study First Received: January 28, 2013
Last Updated: June 24, 2013 processed this record on June 23, 2017