Treatment of Functional Movement Disorders With Psychotherapy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01778517
Recruitment Status : Completed
First Posted : January 29, 2013
Last Update Posted : July 2, 2017
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) )

Brief Summary:


- Functional movement disorder (FMD) is a form of conversion disorder (CD). CD is a disorder in which a person has neurological symptoms that do not have a neurological cause. These symptoms can include pain, weakness, dizziness, and fatigue. Some thoughts on CD suggest that it may come from feelings of anxiety that are converted into physical symptoms. Treatment for FMD usually involves stress reduction, family help, and regular doctor s appointments. Therapy interventions, however, have not been well studied. Researchers want to see if people with FMD get better with psychotherapy. They will study two different types of psychotherapy: group therapy and a self-help manual.


- To test two different types of therapy treatments for FMD.


- Individuals at least 18 years of age who have been diagnosed with FMD by a neurologist.


  • Participants will be screened with a physical exam and medical history. They will also have a psychological exam, and answer questions about their mood and symptoms.
  • Participants will be separated into three groups. One group will have group therapy. Another will use a self-help workbook designed for people with FMD, and have individual therapy sessions. A third group will just have standard care. During the study, participants will continue to see their regular doctor.
  • Group therapy participants will meet once a week for 6 months at the National Institutes of Health clinical center. There will be 8 to 10 people per group. Sessions will last 75 minutes. These sessions will work on methods for treating FMD.
  • Self-help workbook participants will have six individual therapy sessions over 3 to 4 months. They will use the workbooks to learn about and practice methods for treating FMD.
  • All participants will be evaluated at 3, 6, and 12 months during the study.
  • At the end of the study, participants will have a final follow-up session with exams and questions similar to the screening exam. They will return to the care of their regular doctor.

Condition or disease Intervention/treatment Phase
Movement Disorders Other: Group Psychotherapy Other: Cognitive behavior therapy based on self help Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 9 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Treatment of Functional Movement Disorders With Psychotherapy
Study Start Date : December 11, 2012
Actual Primary Completion Date : July 23, 2015
Actual Study Completion Date : July 23, 2015

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Ability to participate in social roles and activities (Neuro-QOL Item Bank) [ Time Frame: 6 months ]

Secondary Outcome Measures :
  1. Somatic symptoms (SCL-90). [ Time Frame: at baseline ]
  2. Self assessment of disease severity (5 point Likert scale). [ Time Frame: 3 months ]
  3. Subjective and objective depressive and anxiety symptoms. [ Time Frame: 6 months ]
  4. Clinical Global impression of severity (CGI). [ Time Frame: 12 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Must have participated in Protocol 07-N-0190 ( Neurobiological studies of psychogenic movement disorder and non-epileptic seizure )
  • Diagnosis of clinically definite FMD utilizing Fahn and Williams criteria. The diagnosis must be made by a neurologist
  • Patients who have active movement symptoms at baseline and score at least 20 percent less than the maximum score on the Neuro-QOL Item Bank
  • Able to give informed consent
  • All participants should be English-speaking
  • Age 18 or older
  • Willingness to come without reimbursement to treatment visits for up to 6 months
  • Willingness to remain on the same medications for the entire duration of the study


  • Have significant neurological disorders (primary or comorbid) such as neurodegenerative disorders, stroke, movement disorders or epilepsy
  • Patients with psychotic disorders or bipolar disorder
  • Patients with history of alcohol and substance use disorders within the last year, as defined by the DSM-IV-TR (nicotine and caffeine use is not criterion for exclusion)
  • Current suicidal/homicidal ideation
  • Disease severity requiring inpatient treatment. Chronic pain requiring treatment with narcotic medication


  • Patients with movement symptoms at rest that may substantially inhibit resolution, comfort, or safety of MRI
  • Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations
  • History of traumatic brain injury with loss of consciousness or amnesia lasting greater than a few seconds
  • Contraindication to MRI
  • Pregnancy
  • Patients with current post-traumatic stress disorder, panic disorder or obsessive compulsive disorders
  • Patients on tricyclic antidepressants or antiepileptic medications.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01778517

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Mark Hallett, M.D. National Institute of Neurological Disorders and Stroke (NINDS)

Responsible Party: National Institute of Neurological Disorders and Stroke (NINDS) Identifier: NCT01778517     History of Changes
Other Study ID Numbers: 130047
First Posted: January 29, 2013    Key Record Dates
Last Update Posted: July 2, 2017
Last Verified: July 23, 2015

Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Neurological Disorders and Stroke (NINDS) ):
Psychogenic Movement Disorders

Additional relevant MeSH terms:
Movement Disorders
Conversion Disorder
Pathologic Processes
Central Nervous System Diseases
Nervous System Diseases
Somatoform Disorders
Mental Disorders