Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease
Aspirin-Exacerbated Respiratory Disease, or AERD, consists of aspirin sensitivity, asthma and nasal polyps. It is currently managed by chronic steroid use, multiple endoscopic sinus surgeries and/or aspirin desensitization. However, these treatments have potential adverse effects.
A theory has been postulated that decreasing the level of dietary salicylates may help in long-term control of disease. A current trial is in the works to evaluate the clinical outcomes of decreased salicylate, but measurements of biochemical markers of disease has not yet been done. The hypothesis is that decreased dietary salicylates will result in a decrease in urinary salicylates and inflammatory markers of disease, cys-leukotrienes, which are typically elevated in this disease.
|Chronic Rhinosinusitis Aspirin Exacerbated Respiratory Disease Asthma Aspirin Sensitivity||Behavioral: Low salicylate diet|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:||Effect of Low Dietary Salicylate on Biochemical Markers of Aspirin Exacerbated Respiratory Disease|
- Urinary levels of Cys-Leukotrienes [ Time Frame: 14 days after commencement ]
- Urinary salicylate levels [ Time Frame: 14 days after enrollment ]
|Study Start Date:||May 2013|
|Study Completion Date:||May 2014|
|Primary Completion Date:||March 2014 (Final data collection date for primary outcome measure)|
Experimental: Low salicylate diet
Patients are to follow a low salicylate diet for one week.
Behavioral: Low salicylate diet
Other Name: Dietary salicylate
No Intervention: Normal diet
Patients are to continue with a normal diet for one week. There is then cross-over after one week for a further week into the intervention group.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01778465
|St. Joseph's Health Care|
|London, Ontario, Canada, N5A 4V2|
|Principal Investigator:||Leigh J Sowerby, MD||Lawson HRI|