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The Role of Mid-Life Adiposity in Functional Brain Connectivity

This study has been terminated.
(This is a basic research study with no clinical data to report)
Sponsor:
Information provided by (Responsible Party):
Medical College of Wisconsin
ClinicalTrials.gov Identifier:
NCT01777789
First received: January 24, 2013
Last updated: February 8, 2016
Last verified: February 2016
  Purpose
The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Condition
Alzheimer's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Role of Mid-Life Adiposity in Functional Brain Connectivity

Resource links provided by NLM:


Further study details as provided by Medical College of Wisconsin:

Primary Outcome Measures:
  • Brain connectivity measured by fMRI [ Time Frame: One visit ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
Blood draw

Enrollment: 60
Study Start Date: December 2012
Study Completion Date: February 2016
Primary Completion Date: February 2016 (Final data collection date for primary outcome measure)
Detailed Description:

Participants will have one visit for:

  • Blood draw
  • Body composition scan
  • Cognitive screen
  • Neurological exam
  • MRI scan

The visit will take approximately 3 hours.

  Eligibility

Ages Eligible for Study:   45 Years to 65 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers from the community
Criteria

Inclusion Criteria:

  • 45-65 years of age
  • Normal memory
  • Right-handed
  • General good physical health

Exclusion Criteria:

  • History of stroke or neurological disease
  • Seizures or head injury with loss of consciousness within the last five years
  • Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
  • Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01777789

Locations
United States, Wisconsin
Medical College of Wisconsin/Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Sponsors and Collaborators
Medical College of Wisconsin
Investigators
Principal Investigator: Piero Antuono, MD Medical College of Wisconsin
  More Information

Responsible Party: Medical College of Wisconsin
ClinicalTrials.gov Identifier: NCT01777789     History of Changes
Other Study ID Numbers: PRO16109 
Study First Received: January 24, 2013
Last Updated: February 8, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by Medical College of Wisconsin:
fMRI
Dementia
Alzheimer's disease
functional neuroimaging
Memory

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 23, 2016