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The Role of Mid-Life Adiposity in Functional Brain Connectivity

This study has been terminated.
(This is a basic research study with no clinical data to report)
Sponsor:
ClinicalTrials.gov Identifier:
NCT01777789
First Posted: January 29, 2013
Last Update Posted: February 9, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Medical College of Wisconsin
  Purpose
The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Condition
Alzheimer's Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Role of Mid-Life Adiposity in Functional Brain Connectivity

Resource links provided by NLM:


Further study details as provided by Medical College of Wisconsin:

Primary Outcome Measures:
  • Brain connectivity measured by fMRI [ Time Frame: One visit ]

Biospecimen Retention:   Samples With DNA
Blood draw

Enrollment: 60
Study Start Date: December 2012
Study Completion Date: February 2016
Primary Completion Date: February 2016 (Final data collection date for primary outcome measure)
Detailed Description:

Participants will have one visit for:

  • Blood draw
  • Body composition scan
  • Cognitive screen
  • Neurological exam
  • MRI scan

The visit will take approximately 3 hours.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   45 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers from the community
Criteria

Inclusion Criteria:

  • 45-65 years of age
  • Normal memory
  • Right-handed
  • General good physical health

Exclusion Criteria:

  • History of stroke or neurological disease
  • Seizures or head injury with loss of consciousness within the last five years
  • Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
  • Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01777789


Locations
United States, Wisconsin
Medical College of Wisconsin/Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Sponsors and Collaborators
Medical College of Wisconsin
Investigators
Principal Investigator: Piero Antuono, MD Medical College of Wisconsin
  More Information

Responsible Party: Medical College of Wisconsin
ClinicalTrials.gov Identifier: NCT01777789     History of Changes
Other Study ID Numbers: PRO16109
First Submitted: January 24, 2013
First Posted: January 29, 2013
Last Update Posted: February 9, 2016
Last Verified: February 2016

Keywords provided by Medical College of Wisconsin:
fMRI
Dementia
Alzheimer's disease
functional neuroimaging
Memory

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders