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The Role of Mid-Life Adiposity in Functional Brain Connectivity

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ClinicalTrials.gov Identifier: NCT01777789
Recruitment Status : Terminated (This is a basic research study with no clinical data to report)
First Posted : January 29, 2013
Last Update Posted : February 9, 2016
Sponsor:
Information provided by (Responsible Party):
Medical College of Wisconsin

Brief Summary:
The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Condition or disease
Alzheimer's Disease

Detailed Description:

Participants will have one visit for:

  • Blood draw
  • Body composition scan
  • Cognitive screen
  • Neurological exam
  • MRI scan

The visit will take approximately 3 hours.


Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Role of Mid-Life Adiposity in Functional Brain Connectivity
Study Start Date : December 2012
Primary Completion Date : February 2016
Study Completion Date : February 2016

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Brain connectivity measured by fMRI [ Time Frame: One visit ]

Biospecimen Retention:   Samples With DNA
Blood draw


Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers from the community
Criteria

Inclusion Criteria:

  • 45-65 years of age
  • Normal memory
  • Right-handed
  • General good physical health

Exclusion Criteria:

  • History of stroke or neurological disease
  • Seizures or head injury with loss of consciousness within the last five years
  • Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner)
  • Claustrophobia

More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01777789


Locations
United States, Wisconsin
Medical College of Wisconsin/Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Sponsors and Collaborators
Medical College of Wisconsin
Investigators
Principal Investigator: Piero Antuono, MD Medical College of Wisconsin

Responsible Party: Medical College of Wisconsin
ClinicalTrials.gov Identifier: NCT01777789     History of Changes
Other Study ID Numbers: PRO16109
First Posted: January 29, 2013    Key Record Dates
Last Update Posted: February 9, 2016
Last Verified: February 2016

Keywords provided by Medical College of Wisconsin:
fMRI
Dementia
Alzheimer's disease
functional neuroimaging
Memory

Additional relevant MeSH terms:
Alzheimer Disease
Dementia
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Tauopathies
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders