Functional Brain Imaging of Pain Phenotype and Genotype
This study has two purposes: first, to locate and identify the "brain activation" (the areas of the brain) which respond to pain; and second, to look at how brain activation is influenced by a person's genetics (the traits they inherited from their parents). A Magnetic Resonance Imaging (MRI) scanner will be used to gather pictures of the brain (similar to an x-ray, but based on different scientific principles) that will be used to determine which areas are active. The hypothesis is that the variation in brain activity between people can be partially explained by genetic differences. This study consists of an two pain tasks applied during a one time visit to the MRI suite. There are no followup visits.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Brain Imaging of Pain Phenotype and Genotype With Novel Scanning Techniques|
- Areas of brain activity from a transcutaneous painful stimulation [ Time Frame: At the conclusion of the 1 hour scanning session; Visit one ] [ Designated as safety issue: No ]A nerve stimulator will be turned on at the level that causes you to report 7/10 pain for 30 seconds, followed by a 30 second period of rest. This will be repeated four times. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
- Areas of brain activity from a 45 minutes Capsaicin cream application [ Time Frame: At the conclusion of the 1 hour scanning session; Visit 1 ] [ Designated as safety issue: No ]The painful stimulation will now be caused by placing a piece of gauze soaked with capsaicin, the active ingredients in chili peppers, on the subject's right arm. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
- Pain phenotyping [ Time Frame: After the 45 minute Capsaicin cream application; Visit 1 ] [ Designated as safety issue: No ]Subjects will report their pain at least every 3 minutes during the cream application. The subject's pain phenotype will be determined from this response.
|Study Start Date:||January 2013|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Experimental: Healthy normal volunteers
Healthy normal volunteers
Other: gauze soaked with capsaicin
This is a basic science study determining the brain activation that results from painful stimulation. All subjects will have the same painful stimulations and brain images collected.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01777087
|Contact: James W Ibinson, MD, PhDfirstname.lastname@example.org|
|United States, Pennsylvania|
|University of Pittsburgh||Recruiting|
|Pittsburgh, Pennsylvania, United States, 15213|
|Contact: James W Ibinson 412-383-5911 email@example.com|
|Principal Investigator: James W Ibinson, MD, PhD|
|Principal Investigator:||James W Ibinson, MD, PhD||University of Pittsburgh|