Functional Brain Imaging of Pain Phenotype and Genotype
|ClinicalTrials.gov Identifier: NCT01777087|
Recruitment Status : Completed
First Posted : January 28, 2013
Last Update Posted : May 2, 2018
|Condition or disease||Intervention/treatment||Phase|
|Pain||Other: gauze soaked with capsaicin||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Brain Imaging of Pain Phenotype and Genotype With Novel Scanning Techniques|
|Study Start Date :||January 2013|
|Actual Primary Completion Date :||March 2016|
|Actual Study Completion Date :||March 2016|
Experimental: Healthy normal volunteers
Healthy normal volunteers
Other: gauze soaked with capsaicin
This is a basic science study determining the brain activation that results from painful stimulation. All subjects will have the same painful stimulations and brain images collected.
- Areas of brain activity from a transcutaneous painful stimulation [ Time Frame: At the conclusion of the 1 hour scanning session; Visit one ]A nerve stimulator will be turned on at the level that causes you to report 7/10 pain for 30 seconds, followed by a 30 second period of rest. This will be repeated four times. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
- Areas of brain activity from a 45 minutes Capsaicin cream application [ Time Frame: At the conclusion of the 1 hour scanning session; Visit 1 ]The painful stimulation will now be caused by placing a piece of gauze soaked with capsaicin, the active ingredients in chili peppers, on the subject's right arm. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
- Pain phenotyping [ Time Frame: After the 45 minute Capsaicin cream application; Visit 1 ]Subjects will report their pain at least every 3 minutes during the cream application. The subject's pain phenotype will be determined from this response.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01777087
|United States, Pennsylvania|
|University of Pittsburgh|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||James W Ibinson, MD, PhD||University of Pittsburgh|