Functional Brain Imaging of Pain Phenotype and Genotype
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|ClinicalTrials.gov Identifier: NCT01777087|
Recruitment Status : Completed
First Posted : January 28, 2013
Last Update Posted : May 2, 2018
|Condition or disease||Intervention/treatment||Phase|
|Pain||Other: gauze soaked with capsaicin||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Brain Imaging of Pain Phenotype and Genotype With Novel Scanning Techniques|
|Study Start Date :||January 2013|
|Actual Primary Completion Date :||March 2016|
|Actual Study Completion Date :||March 2016|
Experimental: Healthy normal volunteers
Healthy normal volunteers
Other: gauze soaked with capsaicin
This is a basic science study determining the brain activation that results from painful stimulation. All subjects will have the same painful stimulations and brain images collected.
- Areas of brain activity from a transcutaneous painful stimulation [ Time Frame: At the conclusion of the 1 hour scanning session; Visit one ]A nerve stimulator will be turned on at the level that causes you to report 7/10 pain for 30 seconds, followed by a 30 second period of rest. This will be repeated four times. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
- Areas of brain activity from a 45 minutes Capsaicin cream application [ Time Frame: At the conclusion of the 1 hour scanning session; Visit 1 ]The painful stimulation will now be caused by placing a piece of gauze soaked with capsaicin, the active ingredients in chili peppers, on the subject's right arm. The areas of brain activity are determined at the end of the 1 hour scanning session by analyzing the brain images. There are no additional followup or long term outcomes.
- Pain phenotyping [ Time Frame: After the 45 minute Capsaicin cream application; Visit 1 ]Subjects will report their pain at least every 3 minutes during the cream application. The subject's pain phenotype will be determined from this response.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01777087
|United States, Pennsylvania|
|University of Pittsburgh|
|Pittsburgh, Pennsylvania, United States, 15213|
|Principal Investigator:||James W Ibinson, MD, PhD||University of Pittsburgh|