Respiratory Function and Walking Capacity in Multiple Sclerosis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2013 by University Hospital Orebro.
Recruitment status was  Active, not recruiting
Örebro County Council
Information provided by (Responsible Party):
Anna Wittrin, University Hospital Orebro Identifier:
First received: January 18, 2013
Last updated: January 22, 2013
Last verified: January 2013

Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages.

The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.

Condition Intervention
Multiple Sclerosis
Respiratory; Disorder, Functional, Impaired
Difficulty Walking
Other: Breathing exercises

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment
Official Title: Respiratory Function and Walking Capacity in Multiple Sclerosis

Resource links provided by NLM:

Further study details as provided by University Hospital Orebro:

Primary Outcome Measures:
  • Respiratory muscle strength [ Time Frame: Two months ] [ Designated as safety issue: No ]
    Maximum expiratory pressure

Estimated Enrollment: 50
Study Start Date: September 2012
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Breathing exercises
Daily deep breathing exercises during two month
Other: Breathing exercises
No Intervention: Control
Control group


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Inhabitant in Örebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval ≥ 3.0 - ≤ 7.0.
  • Participants must understand verbal and written information and must be relapse free ≥ 3 months prior to inclusion.

Exclusion Criteria:

  • Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01774201

Sponsors and Collaborators
University Hospital Orebro
Örebro County Council
Principal Investigator: Elisabeth Westerdahl, Phd Department of Physiotherapy, Örebro University Hospital
  More Information

Responsible Party: Anna Wittrin, Phd, University Hospital Orebro Identifier: NCT01774201     History of Changes
Other Study ID Numbers: OLL-260361 
Study First Received: January 18, 2013
Last Updated: January 22, 2013
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by University Hospital Orebro:
Multiple sclerosis
Physical endurance
Respiratory function

Additional relevant MeSH terms:
Multiple Sclerosis
Respiration Disorders
Autoimmune Diseases
Autoimmune Diseases of the Nervous System
Demyelinating Autoimmune Diseases, CNS
Demyelinating Diseases
Immune System Diseases
Nervous System Diseases
Pathologic Processes
Respiratory Tract Diseases processed this record on May 22, 2016