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Effects of Phenolic Acids on Endothelial Function

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ClinicalTrials.gov Identifier: NCT01772784
Recruitment Status : Completed
First Posted : January 21, 2013
Last Update Posted : January 21, 2013
Information provided by (Responsible Party):

Study Description
Brief Summary:
Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Condition or disease Intervention/treatment
Healthy Other: Phenolic acids

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 24 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Study Start Date : June 2012
Primary Completion Date : November 2012
Study Completion Date : November 2012
Arms and Interventions

Arm Intervention/treatment
Experimental: phenolic acids
Maltodextrine + Phenolic acids
Other: Phenolic acids
Phenolic acids
Placebo Comparator: placebo
Other: Phenolic acids
Phenolic acids
Experimental: phenolic acid
Maltodextrine + Phenolic acids
Other: Phenolic acids
Phenolic acids
Active Comparator: polyphenol Other: Phenolic acids
Phenolic acids

Outcome Measures

Primary Outcome Measures :
  1. endothelial dysfunction [ Time Frame: 1 hour ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy
  • males
  • Smokers

Exclusion Criteria:

Any food allergy

  • Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg
  • Regular consumption of medication within 2 months before the study inclusion
  • Caffeine intake 1 day before screening measurements (and 1 day before each visit),
  • Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
  • Excessive alcohol intake defined as > 280 g per week
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01772784

Swiss Cardiovascular Center Bern, University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
Principal Investigator: Yves Allemann, MD, Prof. University Hospital, Bern, Switzerland
More Information

Responsible Party: Nestlé
ClinicalTrials.gov Identifier: NCT01772784     History of Changes
Other Study ID Numbers: 11.36.NRC
First Posted: January 21, 2013    Key Record Dates
Last Update Posted: January 21, 2013
Last Verified: November 2012

Keywords provided by Nestlé: