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Effects of Phenolic Acids on Endothelial Function

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01772784
First Posted: January 21, 2013
Last Update Posted: January 21, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Nestlé
  Purpose
Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Condition Intervention
Healthy Other: Phenolic acids

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)

Further study details as provided by Nestlé:

Primary Outcome Measures:
  • endothelial dysfunction [ Time Frame: 1 hour ]

Enrollment: 24
Study Start Date: June 2012
Study Completion Date: November 2012
Primary Completion Date: November 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: phenolic acids
Maltodextrine + Phenolic acids
Other: Phenolic acids
Phenolic acids
Placebo Comparator: placebo
Maltodextrine
Other: Phenolic acids
Phenolic acids
Experimental: phenolic acid
Maltodextrine + Phenolic acids
Other: Phenolic acids
Phenolic acids
Active Comparator: polyphenol Other: Phenolic acids
Phenolic acids

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • males
  • Smokers

Exclusion Criteria:

Any food allergy

  • Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg
  • Regular consumption of medication within 2 months before the study inclusion
  • Caffeine intake 1 day before screening measurements (and 1 day before each visit),
  • Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
  • Excessive alcohol intake defined as > 280 g per week
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01772784


Locations
Switzerland
Swiss Cardiovascular Center Bern, University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
Nestlé
Investigators
Principal Investigator: Yves Allemann, MD, Prof. University Hospital, Bern, Switzerland
  More Information

Responsible Party: Nestlé
ClinicalTrials.gov Identifier: NCT01772784     History of Changes
Other Study ID Numbers: 11.36.NRC
First Submitted: July 25, 2012
First Posted: January 21, 2013
Last Update Posted: January 21, 2013
Last Verified: November 2012

Keywords provided by Nestlé:
subjects