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Effects of Phenolic Acids on Endothelial Function

This study has been completed.
Information provided by (Responsible Party):
Nestlé Identifier:
First received: July 25, 2012
Last updated: January 17, 2013
Last verified: November 2012
Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Condition Intervention
Healthy Other: Phenolic acids

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)

Further study details as provided by Nestlé:

Primary Outcome Measures:
  • endothelial dysfunction [ Time Frame: 1 hour ]

Enrollment: 24
Study Start Date: June 2012
Study Completion Date: November 2012
Primary Completion Date: November 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: phenolic acids
Maltodextrine + Phenolic acids
Other: Phenolic acids
Phenolic acids
Placebo Comparator: placebo
Other: Phenolic acids
Phenolic acids
Experimental: phenolic acid
Maltodextrine + Phenolic acids
Other: Phenolic acids
Phenolic acids
Active Comparator: polyphenol Other: Phenolic acids
Phenolic acids


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy
  • males
  • Smokers

Exclusion Criteria:

Any food allergy

  • Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg
  • Regular consumption of medication within 2 months before the study inclusion
  • Caffeine intake 1 day before screening measurements (and 1 day before each visit),
  • Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
  • Excessive alcohol intake defined as > 280 g per week
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01772784

Swiss Cardiovascular Center Bern, University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
Principal Investigator: Yves Allemann, MD, Prof. University Hospital, Bern, Switzerland
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Nestlé Identifier: NCT01772784     History of Changes
Other Study ID Numbers: 11.36.NRC
Study First Received: July 25, 2012
Last Updated: January 17, 2013

Keywords provided by Nestlé:
subjects processed this record on September 19, 2017