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Measurement of Retinal Venous Pressure Under Short-term Low-oxygen Environment

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland Identifier:
First received: October 24, 2012
Last updated: July 18, 2014
Last verified: July 2014
The hypothesis is that the pressure in the retinal veins increases under a short-term lack of oxygen and leads to a decreased blood circulation. On the basis of measurements in the hypobaric chamber this hypothesis should be verified.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurement of Retinal Venous Pressure (Retinal Venous Pressure RVP) Under Conditions of Reduced Ambient Pressure and Oxygen Partial Pressure

Resource links provided by NLM:

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • Retinal venous pressure [ Time Frame: 1 hour ]
    Quantify the changes in the retinal venous pressure (RVP)

Enrollment: 24
Study Start Date: December 2011
Study Completion Date: July 2014
Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Detailed Description:
Conduct a pilot study to describe and quantify the retinal venous pressure (RVP) in healthy volunteers under conditions of controlled, reduced ambient and oxygen partial pressure in the pressure chamber of the Aeromedical Institute FAI in Dübendorf, Switzerland. Obtaining evidence of the adaptation behavior of the retinal vascular system in controlled, short-term hypoxic changes.

Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy volunteers

Inclusion Criteria:

  • healthy

Exclusion Criteria:

  • eye diseases
  • systemic diseases
  • term medication (except contraceptives)
  • pregnancy
  • allergies to the ingredients Alcain, Tropicamide and Phenylephrine
  • blood pressure levels except standard (<60 /> 140 mmHg)
  • oxygen saturation (SO2) <90%
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Please refer to this study by its identifier: NCT01771757

University of Basel, Dept. of Ophthalmology
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Study Director: Josef Flammer, MD University of Basel, Dept. of Ophthalmology
  More Information

Responsible Party: University Hospital, Basel, Switzerland Identifier: NCT01771757     History of Changes
Other Study ID Numbers: USB-2011-327
Study First Received: October 24, 2012
Last Updated: July 18, 2014

Keywords provided by University Hospital, Basel, Switzerland:
retinal venous pressure
reduced ambient pressure
oxygen partial pressure
short-term hypoxic changes processed this record on May 25, 2017