Measurement of Retinal Venous Pressure Under Short-term Low-oxygen Environment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01771757
Recruitment Status : Completed
First Posted : January 18, 2013
Last Update Posted : July 21, 2014
Information provided by (Responsible Party):
University Hospital, Basel, Switzerland

Brief Summary:
The hypothesis is that the pressure in the retinal veins increases under a short-term lack of oxygen and leads to a decreased blood circulation. On the basis of measurements in the hypobaric chamber this hypothesis should be verified.

Condition or disease

Detailed Description:
Conduct a pilot study to describe and quantify the retinal venous pressure (RVP) in healthy volunteers under conditions of controlled, reduced ambient and oxygen partial pressure in the pressure chamber of the Aeromedical Institute FAI in Dübendorf, Switzerland. Obtaining evidence of the adaptation behavior of the retinal vascular system in controlled, short-term hypoxic changes.

Study Type : Observational
Actual Enrollment : 24 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurement of Retinal Venous Pressure (Retinal Venous Pressure RVP) Under Conditions of Reduced Ambient Pressure and Oxygen Partial Pressure
Study Start Date : December 2011
Primary Completion Date : May 2014
Study Completion Date : July 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Oxygen Therapy
U.S. FDA Resources

Primary Outcome Measures :
  1. Retinal venous pressure [ Time Frame: 1 hour ]
    Quantify the changes in the retinal venous pressure (RVP)

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
healthy volunteers

Inclusion Criteria:

  • healthy

Exclusion Criteria:

  • eye diseases
  • systemic diseases
  • term medication (except contraceptives)
  • pregnancy
  • allergies to the ingredients Alcain, Tropicamide and Phenylephrine
  • blood pressure levels except standard (<60 /> 140 mmHg)
  • oxygen saturation (SO2) <90%

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01771757

University of Basel, Dept. of Ophthalmology
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Study Director: Josef Flammer, MD University of Basel, Dept. of Ophthalmology

Responsible Party: University Hospital, Basel, Switzerland Identifier: NCT01771757     History of Changes
Other Study ID Numbers: USB-2011-327
First Posted: January 18, 2013    Key Record Dates
Last Update Posted: July 21, 2014
Last Verified: July 2014

Keywords provided by University Hospital, Basel, Switzerland:
retinal venous pressure
reduced ambient pressure
oxygen partial pressure
short-term hypoxic changes