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Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy

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ClinicalTrials.gov Identifier: NCT01771718
Recruitment Status : Withdrawn (Not a clinical trial study)
First Posted : January 18, 2013
Last Update Posted : August 25, 2017
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin lesions for characterization of their morphologic and functional features. .

Condition or disease Intervention/treatment
Skin Lesion Device: MPTflex-multiphoton microscopy-based tomograph.

Detailed Description:

This study is performed using a multiphoton microscopy-based tomograph (MPTflex) developed by JenLab, GmbH (Germany) to image non-invasively normal and lesional skin. Skin lesions are imaged by multiphoton microscopy and images are compared to those obtained from histopathology through standard of care processed skin biopsies.

Any biopsies will be performed by the health care provider as a standard of care procedure.

Study Design

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Non-invasive Skin Imaging Using Multiphoton Microscopy
Study Start Date : April 2012
Estimated Primary Completion Date : June 2018
Estimated Study Completion Date : June 2018
Groups and Cohorts

Group/Cohort Intervention/treatment
Human skin
Multiphoton microscopy imaging to collect information about changes in skin cells and fibrilar structure.
Device: MPTflex-multiphoton microscopy-based tomograph.
non-invasive optical biopsy

Outcome Measures

Primary Outcome Measures :
  1. high-resolution images of skin [ Time Frame: up to 12 months ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Study population will be selected from University of California Irvine Medical Clinic

Inclusion Criteria:

  • Male or Female all age groups
  • Ability to understand and carry out subject instructions

Exclusion Criteria:

  • Pregnant women
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01771718

United States, California
Beckman Laser Institute Medical Clinic
Irvine, California, United States, 92612
Sponsors and Collaborators
University of California, Irvine
Beckman Laser Institute University of California Irvine
Principal Investigator: Kristen Kelly, MD Beckman Laser Institute, UCI
More Information

Responsible Party: Beckman Laser Institute and Medical Center, Kristen Kelly M.D.,Professor Departments of Dermatology and Surgery, University of California, Irvine
ClinicalTrials.gov Identifier: NCT01771718     History of Changes
Other Study ID Numbers: NIH/LAMMP-2011-8494
First Posted: January 18, 2013    Key Record Dates
Last Update Posted: August 25, 2017
Last Verified: August 2017