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Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

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ClinicalTrials.gov Identifier: NCT01770938
Recruitment Status : Completed
First Posted : January 18, 2013
Last Update Posted : September 23, 2014
Sponsor:
Collaborators:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Centro de Pequisas de Ótica e Fotônica
Information provided by (Responsible Party):
Cleber Ferraresi, Universidade Federal de Sao Carlos

Brief Summary:
Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Condition or disease Intervention/treatment Phase
Healthy Device: Effective light-emitting diode therapy Device: Placebo light-emitting diode therapy Not Applicable

Detailed Description:
This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 32 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training
Study Start Date : May 2012
Actual Primary Completion Date : July 2012
Actual Study Completion Date : September 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Effective light-emitting diode therapy and training
Effects of effective light-emitting diode therapy therapy on muscle performance of young males submitted to physical strength training
Device: Effective light-emitting diode therapy
Other Names:
  • LED
  • LED therapy
  • Light-emitting diode therapy

Placebo Comparator: Placebo light-emitting diode therapy and training
Effects of placebo light-emitting diode therapy on muscle performance of young males submitted to physical strength training
Device: Placebo light-emitting diode therapy
Other Names:
  • LED
  • LED therapy
  • Light-emitting diode therapy




Primary Outcome Measures :
  1. Modulations on muscle gene expression by RT-PCR [ Time Frame: 12 weeks ]

Secondary Outcome Measures :
  1. Muscle performance in leg press device [ Time Frame: 12 weeks ]
  2. Muscle performance in leg extension device [ Time Frame: 12 weeks ]
  3. Muscle performance in isokinetic dynamometer [ Time Frame: 12 weeks ]
  4. Gene expression [ Time Frame: 12 weeks ]
    Gene expression of muscle tissue by RT-PCR


Other Outcome Measures:
  1. Immunohistochemical analysis [ Time Frame: 12 weeks ]
    Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.



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Ages Eligible for Study:   18 Years to 28 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2,
  • moderated pattern of physical activity

Exclusion Criteria:

  • previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
  • osseous or articular disorder in the lower limbs,
  • cardiovascular system disorders,
  • systemic disease, and
  • taking prescription medicines or using dietary supplements such as muscle mass builders.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01770938


Locations
Brazil
Federal University of São Carlos
São Carlos, São Paulo, Brazil, 13565-905
Sponsors and Collaborators
Universidade Federal de Sao Carlos
Fundação de Amparo à Pesquisa do Estado de São Paulo
Centro de Pequisas de Ótica e Fotônica
Investigators
Principal Investigator: Cleber Ferraresi, MSc Universidade Federal de Sao Carlos
Study Director: Nivaldo A Parizotto, PhD Universidade Federal de Sao Carlos
Study Director: Vanderlei S Bagnato, PhD University of São Paulo