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Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01770938
First Posted: January 18, 2013
Last Update Posted: September 23, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Centro de Pequisas de Ótica e Fotônica
Information provided by (Responsible Party):
Cleber Ferraresi, Universidade Federal de Sao Carlos
  Purpose
Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Condition Intervention
Healthy Device: Effective light-emitting diode therapy Device: Placebo light-emitting diode therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Further study details as provided by Cleber Ferraresi, Universidade Federal de Sao Carlos:

Primary Outcome Measures:
  • Modulations on muscle gene expression by RT-PCR [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Muscle performance in leg press device [ Time Frame: 12 weeks ]
  • Muscle performance in leg extension device [ Time Frame: 12 weeks ]
  • Muscle performance in isokinetic dynamometer [ Time Frame: 12 weeks ]
  • Gene expression [ Time Frame: 12 weeks ]
    Gene expression of muscle tissue by RT-PCR


Other Outcome Measures:
  • Immunohistochemical analysis [ Time Frame: 12 weeks ]
    Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.


Enrollment: 32
Study Start Date: May 2012
Study Completion Date: September 2014
Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Effective light-emitting diode therapy and training
Effects of effective light-emitting diode therapy therapy on muscle performance of young males submitted to physical strength training
Device: Effective light-emitting diode therapy
Other Names:
  • LED
  • LED therapy
  • Light-emitting diode therapy
Placebo Comparator: Placebo light-emitting diode therapy and training
Effects of placebo light-emitting diode therapy on muscle performance of young males submitted to physical strength training
Device: Placebo light-emitting diode therapy
Other Names:
  • LED
  • LED therapy
  • Light-emitting diode therapy

Detailed Description:
This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 28 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2,
  • moderated pattern of physical activity

Exclusion Criteria:

  • previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
  • osseous or articular disorder in the lower limbs,
  • cardiovascular system disorders,
  • systemic disease, and
  • taking prescription medicines or using dietary supplements such as muscle mass builders.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01770938


Locations
Brazil
Federal University of São Carlos
São Carlos, São Paulo, Brazil, 13565-905
Sponsors and Collaborators
Universidade Federal de Sao Carlos
Fundação de Amparo à Pesquisa do Estado de São Paulo
Centro de Pequisas de Ótica e Fotônica
Investigators
Principal Investigator: Cleber Ferraresi, MSc Universidade Federal de Sao Carlos
Study Director: Nivaldo A Parizotto, PhD Universidade Federal de Sao Carlos
Study Director: Vanderlei S Bagnato, PhD University of São Paulo
  More Information

Publications:
Responsible Party: Cleber Ferraresi, MSc, Universidade Federal de Sao Carlos
ClinicalTrials.gov Identifier: NCT01770938     History of Changes
Other Study ID Numbers: CAAE: 0326.0.135.000-11
First Submitted: September 15, 2012
First Posted: January 18, 2013
Last Update Posted: September 23, 2014
Last Verified: September 2014

Keywords provided by Cleber Ferraresi, Universidade Federal de Sao Carlos:
Light-emitting diode therapy
Muscle performance
Gene expression
Functional performance