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Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism (NMDA-Autism)
This study has been completed.
Sponsor:
University Hospital, Tours
Information provided by (Responsible Party):
University Hospital, Tours
ClinicalTrials.gov Identifier:
NCT01770548
First received: January 15, 2013
Last updated: January 13, 2017
Last verified: January 2017
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Purpose
Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism
| Condition | Intervention |
|---|---|
| Autism | Genetic: analysis of the glutamate synapse in autism Genetic: DNA collection Other: Auditory evoked potentials |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) |
| Official Title: | Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers. |
Further study details as provided by University Hospital, Tours:
Primary Outcome Measures:
- screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients [ Time Frame: two years ]
| Enrollment: | 497 |
| Study Start Date: | January 2009 |
| Study Completion Date: | June 2014 |
| Primary Completion Date: | January 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Autism
Analysis of the glutamate synapse in autism
|
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
|
|
Relative
Analysis of the glutamate synapse in autism
|
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
|
|
Major control
DNA collection
|
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
|
|
Minor control
auditory evoked potentials
|
Other: Auditory evoked potentials
auditory evoked potentials
|
Detailed Description:
Analysis about 50 genes in glutamate synapse
Eligibility| Ages Eligible for Study: | 2 Years and older (Child, Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- have a Pervasive Developmental Disorder
Exclusion Criteria:
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01770548
Please refer to this study by its ClinicalTrials.gov identifier: NCT01770548
Locations
| France | |
| CHRU - Centre de Ressources Autisme (CRA) | |
| Brest, France, 29000 | |
| CHS du ROUVRAY | |
| Rouen, France, 76000 | |
| Chru - Cic | |
| Tours, France, 37000 | |
| CHRU - Pédopsychiatrie | |
| Tours, France, F-37000 | |
Sponsors and Collaborators
University Hospital, Tours
Investigators
| Study Director: | Frédérique BONNET-BRILHAULT, MD PHD | University François Rabelais of TOURS |
More Information
Publications:
| Responsible Party: | University Hospital, Tours |
| ClinicalTrials.gov Identifier: | NCT01770548 History of Changes |
| Other Study ID Numbers: |
AORT08-FBB/NMDA-Autism 2008-A01162-53 ( Other Identifier: ID RCB ) |
| Study First Received: | January 15, 2013 |
| Last Updated: | January 13, 2017 |
Additional relevant MeSH terms:
|
Autistic Disorder Child Development Disorders, Pervasive Neurodevelopmental Disorders Mental Disorders |
ClinicalTrials.gov processed this record on August 23, 2017