Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism (NMDA-Autism)

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

University Hospital, Tours

ClinicalTrials.gov Identifier:

NCT01770548

First received: January 15, 2013

Last updated: January 13, 2017

Last verified: January 2017

History of Changes

Purpose

Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism

Condition	Intervention
Autism	Genetic: analysis of the glutamate synapse in autism Genetic: DNA collection Other: Auditory evoked potentials


Study Type:	Interventional
Study Design:	Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label
Official Title:	Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.

Further study details as provided by University Hospital, Tours:

Primary Outcome Measures:

screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients [ Time Frame: two years ]


Enrollment:	497
Study Start Date:	January 2009
Study Completion Date:	June 2014
Primary Completion Date:	January 2011 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: Autism Analysis of the glutamate synapse in autism	Genetic: analysis of the glutamate synapse in autism Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism Genetic: DNA collection DNA collection Other: Auditory evoked potentials auditory evoked potentials
Relative Analysis of the glutamate synapse in autism	Genetic: analysis of the glutamate synapse in autism Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism Genetic: DNA collection DNA collection Other: Auditory evoked potentials auditory evoked potentials
Major control DNA collection	Genetic: analysis of the glutamate synapse in autism Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism Genetic: DNA collection DNA collection Other: Auditory evoked potentials auditory evoked potentials
Minor control auditory evoked potentials	Other: Auditory evoked potentials auditory evoked potentials

Detailed Description:

Analysis about 50 genes in glutamate synapse

Eligibility


Ages Eligible for Study:	2 Years and older (Child, Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

have a Pervasive Developmental Disorder

Exclusion Criteria:

Contacts and Locations

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Please refer to this study by its ClinicalTrials.gov identifier: NCT01770548

Locations


France
CHRU - Centre de Ressources Autisme (CRA)
Brest, France, 29000
CHS du ROUVRAY
Rouen, France, 76000
Chru - Cic
Tours, France, 37000
CHRU - Pédopsychiatrie
Tours, France, F-37000

Sponsors and Collaborators

University Hospital, Tours

Investigators


Study Director:	Frédérique BONNET-BRILHAULT, MD PHD	University François Rabelais of TOURS

More Information

Publications:

Bonnet-Brilhault F, Alirol S, Blanc R, Bazaud S, Marouillat S, Thépault RA, Andres CR, Lemonnier É, Barthélémy C, Raynaud M, Toutain A, Gomot M, Laumonnier F. GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability. Mol Psychiatry. 2016 Mar;21(3):411-8. doi: 10.1038/mp.2015.75. Epub 2015 Jun 9.


Responsible Party:	University Hospital, Tours
ClinicalTrials.gov Identifier:	NCT01770548 History of Changes
Other Study ID Numbers:	AORT08-FBB/NMDA-Autism 2008-A01162-53 ( Other Identifier: ID RCB )
Study First Received:	January 15, 2013
Last Updated:	January 13, 2017

Additional relevant MeSH terms:


Autistic Disorder Child Development Disorders, Pervasive Neurodevelopmental Disorders Mental Disorders

ClinicalTrials.gov processed this record on May 22, 2017

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