Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism (NMDA-Autism)
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ClinicalTrials.gov Identifier: NCT01770548 |
Recruitment Status
:
Completed
First Posted
: January 17, 2013
Last Update Posted
: January 16, 2017
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Autism | Genetic: analysis of the glutamate synapse in autism Genetic: DNA collection Other: Auditory evoked potentials | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 497 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Official Title: | Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers. |
Study Start Date : | January 2009 |
Actual Primary Completion Date : | January 2011 |
Actual Study Completion Date : | June 2014 |
Arm | Intervention/treatment |
---|---|
Experimental: Autism
Analysis of the glutamate synapse in autism
|
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
|
Relative
Analysis of the glutamate synapse in autism
|
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
|
Major control
DNA collection
|
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
|
Minor control
auditory evoked potentials
|
Other: Auditory evoked potentials
auditory evoked potentials
|
- screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients [ Time Frame: two years ]

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Ages Eligible for Study: | 2 Years and older (Child, Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- have a Pervasive Developmental Disorder
Exclusion Criteria:

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01770548
France | |
CHRU - Centre de Ressources Autisme (CRA) | |
Brest, France, 29000 | |
CHS du ROUVRAY | |
Rouen, France, 76000 | |
Chru - Cic | |
Tours, France, 37000 | |
CHRU - Pédopsychiatrie | |
Tours, France, F-37000 |
Study Director: | Frédérique BONNET-BRILHAULT, MD PHD | University François Rabelais of TOURS |
Publications of Results:
Responsible Party: | University Hospital, Tours |
ClinicalTrials.gov Identifier: | NCT01770548 History of Changes |
Other Study ID Numbers: |
AORT08-FBB/NMDA-Autism 2008-A01162-53 ( Other Identifier: ID RCB ) |
First Posted: | January 17, 2013 Key Record Dates |
Last Update Posted: | January 16, 2017 |
Last Verified: | January 2017 |
Additional relevant MeSH terms:
Autistic Disorder Child Development Disorders, Pervasive Neurodevelopmental Disorders Mental Disorders |