Development of Non-invasive Method for Quantifying Vitamin D Levels in the Body Using Spectroscopy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01770262
Recruitment Status : Withdrawn
First Posted : January 17, 2013
Last Update Posted : January 5, 2016
Ruppin Acdemic Center
Information provided by (Responsible Party):
Hadassah Medical Organization

Brief Summary:

Lack in vitamin D reduces the absorption of calcium in the body, accelerates bone loss and may increase the risk of fractures due to osteoporosis. An algorithm that will allow immediate and non-invasive quantification of vitamin D levels will shorten the time of diagnosis, reduce lab costs and prevent hazards or discomfort to the patient associated with a blood test.

The goal of the study is therefore to develop a non-invasive method for quantifying vitamin D levels in the body using spectroscopy.

40 subjects will be recruited: 20 hospitalized patients in the rehabilitation department, diagnosed with osteoporosis and 20 healthy subjects. Spectroscopy will be used with visible light on the subject's skin and middle infrared (MIR) on the blood sample to find correlation with the chemical lab test results.

Condition or disease

  Show Detailed Description

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Study Start Date : December 2012
Estimated Primary Completion Date : December 2013
Estimated Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Hospitalized subjects diagnosed with osteoporosis

Primary Outcome Measures :
  1. Vitamin D levels [ Time Frame: At baseline ]
    No followup will be performed.

Biospecimen Retention:   Samples Without DNA
Blood samples for quantification of vitamin D levels

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

40 subjects aged 18 years and above will be recruited for this research: 20 patients be recruited from the population of patients in the rehabilitation department who were diagnosed with osteoporosis. Also, we will recruit 20 healthy subjects.

All participants will be able to understand the study protocol and sign a consent form independently.


Inclusion Criteria:

Exclusion Criteria:

  • Pregnant
  • Cannot understand or sign a consent form independently

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01770262

Hillel Yaffe Medical Center
Hadera, Israel, 38100
Sponsors and Collaborators
Hadassah Medical Organization
Ruppin Acdemic Center
Principal Investigator: Mordechi Hallak, MD, MPA Hillel Yaffe Medical Center
Study Director: Sigal Portnoy, PhD Hadassah Medical Center
Study Director: ben zion Dekel, PhD Rupin academic center

Responsible Party: Hadassah Medical Organization Identifier: NCT01770262     History of Changes
Other Study ID Numbers: DVitamin-HMO-CTIL
First Posted: January 17, 2013    Key Record Dates
Last Update Posted: January 5, 2016
Last Verified: December 2012

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases