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Decoding Chronic Pain With fMRI

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ClinicalTrials.gov Identifier: NCT01766973
Recruitment Status : Completed
First Posted : January 11, 2013
Last Update Posted : June 8, 2018
Sponsor:
Information provided by (Responsible Party):
Dr Ben Seymour, University of Cambridge

Brief Summary:
Recent evidence suggests that chronic pain is associated with abnormal connectivity between brain regions associated with the processing of pain. We aim to test the diagnostic power of resting state functional magnetic resonance imaging (MRI) to diagnose patients with chronic back pain. Using new methods of image acquisition and analysis we aim to develop a computational method to correctly classify patients and matched control subjects.

Condition or disease
Chronic Back Pain

Study Type : Observational
Actual Enrollment : 76 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Observational Study to Determine Abnormalities in Resting State fMRI in Chronic Back Pain.
Actual Study Start Date : April 6, 2013
Actual Primary Completion Date : April 6, 2016
Actual Study Completion Date : June 6, 2018

Resource links provided by the National Library of Medicine


Group/Cohort
Chronic back pain
Adults, >6months duration
Control
Age and sex matched controls



Primary Outcome Measures :
  1. Functional brain connectivity [ Time Frame: 6 months ]
    Assessed by fMRI



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adults with >6 months of mechanical lower back pain, not sue to any major systemic disease
Criteria

Inclusion Criteria:

  • age 18-60
  • pain > 6months
  • right-handed
  • non-smoking
  • mechanical back pain

Exclusion Criteria:

  • significant neurological or psychiatric disease
  • major systemic illness
  • MRI exclusion criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01766973


Locations
United Kingdom
Addenbrookes Hospital
Cambridge, United Kingdom, CB2 0QQ
Sponsors and Collaborators
University of Cambridge
Investigators
Principal Investigator: Ben Seymour, MRCP PhD University of Cambridge

Responsible Party: Dr Ben Seymour, Wellcome Intermediate Clinical Fellow, University of Cambridge
ClinicalTrials.gov Identifier: NCT01766973     History of Changes
Other Study ID Numbers: CE-U.NA.NFLT.EGDF
First Posted: January 11, 2013    Key Record Dates
Last Update Posted: June 8, 2018
Last Verified: June 2018

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Additional relevant MeSH terms:
Back Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms