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Generation 100: Blood Volume and Cardiac Function in Healthy Aging

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01765816
First Posted: January 10, 2013
Last Update Posted: January 28, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Norwegian University of Science and Technology
  Purpose

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.


Condition Intervention
Ageing Behavioral: high intensity interval training Behavioral: moderate intensity training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • total blood volume [ Time Frame: 24 hours ]
    carbon monoxide-rebreathing spirometry (Bayreuth, Germany)


Secondary Outcome Measures:
  • hemoglobin volume [ Time Frame: 24 hours ]
    carbon monoxide-rebreathing spirometry (Bayreuth, Germany)


Enrollment: 25
Study Start Date: August 2012
Study Completion Date: November 2014
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: high intensity interval training
one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate
Behavioral: high intensity interval training Behavioral: moderate intensity training
Active Comparator: moderate intensity training
45 minutes of moderate continuous training at 75% of maximal heart rate
Behavioral: high intensity interval training Behavioral: moderate intensity training

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   70 Years to 75 Years   (Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • ability to walk at least 1km,
  • born in 1938,1939,1940,1941 or 1942
  • Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion Criteria:

  • Illness or disability that precludes exercise or hinders completion of the study
  • Uncontrolled hypertension
  • Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
  • Active cancer
  • Test results indicating that study participation is unsafe
  • Inclusion in other studies conflicting with participation in this one
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01765816


Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7006
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Study Chair: Ulrik Wisløff, Professor Norwegian University of Science and Technology
  More Information

Additional Information:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01765816     History of Changes
Other Study ID Numbers: Gen-100-sub1
First Submitted: January 8, 2013
First Posted: January 10, 2013
Last Update Posted: January 28, 2015
Last Verified: January 2015

Keywords provided by Norwegian University of Science and Technology:
Exercise
Elderly
Blood volume
Hemoglobin