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Generation 100: Blood Volume and Cardiac Function in Healthy Aging

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ClinicalTrials.gov Identifier: NCT01765816
Recruitment Status : Completed
First Posted : January 10, 2013
Last Update Posted : January 28, 2015
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.


Condition or disease Intervention/treatment Phase
Ageing Behavioral: high intensity interval training Behavioral: moderate intensity training Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 25 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study
Study Start Date : August 2012
Actual Primary Completion Date : February 2014
Actual Study Completion Date : November 2014

Arm Intervention/treatment
Experimental: high intensity interval training
one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate
Behavioral: high intensity interval training
Behavioral: moderate intensity training
Active Comparator: moderate intensity training
45 minutes of moderate continuous training at 75% of maximal heart rate
Behavioral: high intensity interval training
Behavioral: moderate intensity training



Primary Outcome Measures :
  1. total blood volume [ Time Frame: 24 hours ]
    carbon monoxide-rebreathing spirometry (Bayreuth, Germany)


Secondary Outcome Measures :
  1. hemoglobin volume [ Time Frame: 24 hours ]
    carbon monoxide-rebreathing spirometry (Bayreuth, Germany)



Information from the National Library of Medicine

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Ages Eligible for Study:   70 Years to 75 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • ability to walk at least 1km,
  • born in 1938,1939,1940,1941 or 1942
  • Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion Criteria:

  • Illness or disability that precludes exercise or hinders completion of the study
  • Uncontrolled hypertension
  • Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
  • Active cancer
  • Test results indicating that study participation is unsafe
  • Inclusion in other studies conflicting with participation in this one

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01765816


Locations
Norway
Norwegian University of Science and Technology
Trondheim, Norway, 7006
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
Study Chair: Ulrik Wisløff, Professor Norwegian University of Science and Technology

Additional Information:
Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01765816     History of Changes
Other Study ID Numbers: Gen-100-sub1
First Posted: January 10, 2013    Key Record Dates
Last Update Posted: January 28, 2015
Last Verified: January 2015

Keywords provided by Norwegian University of Science and Technology:
Exercise
Elderly
Blood volume
Hemoglobin