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Clinical and Economic Impact of an Electronic Medical Record Interfaced Decision Support System for Minimizing Severe Drug-Drug Interactions (DDI+)

This study has been completed.
Information provided by (Responsible Party):
Leumit Health Services Identifier:
First received: January 9, 2013
Last updated: October 20, 2014
Last verified: October 2014
Leumit Health Services, an health maintenance organization operating in Israel, will incorporate a web-based, decision support system for handling drug-drug interactions and drug information, termed DDI+. the investigators hypothesize that implementing such a system will reduce health-care expenditures (e.g., hospital admissions, referrals to ERs, Imaging procedures).

Condition Intervention
Healthcare Other: DDI+

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research

Resource links provided by NLM:

Further study details as provided by Leumit Health Services:

Primary Outcome Measures:
  • Hospital Admissions [ Time Frame: up to 12 months post initiation ]

Enrollment: 715
Study Start Date: January 2013
Study Completion Date: October 2014
Primary Completion Date: October 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: DDI+
DDI+ Incorporated in routine ambulatory practice
Other: DDI+
No Intervention: Control
Standard care


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Number of chronic concomitant drugs ≥5

Exclusion Criteria:

  • Patients diagnosed with HIV/AIDS, and/or viral hepatitis B or C.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01765595

Leumit Health Services
Tel-Aviv, Israel
Sponsors and Collaborators
Leumit Health Services
Principal Investigator: Abraham Weizman, MD Tel Aviv University
  More Information

Responsible Party: Leumit Health Services Identifier: NCT01765595     History of Changes
Other Study ID Numbers: LHS012013
Study First Received: January 9, 2013
Last Updated: October 20, 2014

Keywords provided by Leumit Health Services:
health care expenditure
drug drug interactions
electronic decision support systems
Potential reduction processed this record on September 19, 2017