Treatment Use of 3,4-Diaminopyridine
This is a continuing project to provide 3,4 diaminopyridine (DAP) under a treatment-use IND to patients with Lambert-Eaton myasthenic syndrome (LEMS) and congenital myasthenic syndrome (CMS).
Lambert Eaton Myasthenic Syndrome (LEMS)
Myasthenic Syndromes, Congenital
|Study Type:||Expanded Access What is Expanded Access?|
|Official Title:||Treatment Use of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome and Congenital Myasthenia Gravis|
The diagnosis of LEMS or CMS will have been made based on clinical and electromyographic findings, and all patients will have been referred to the PI for DAP treatment. This study will enroll minors and adults.
CMS patients under age 18 years will be included if their parent or guardian gives written permission. Minors who turn 18 while in the program will be re-consented as adults.
The dose of DAP will be determined individually for each patient. Adults will start with a dose of 10 mg 3-4 times daily, increasing over several weeks to the dose that produces the maximum symptomatic response, not to exceed 100 mg daily. Pyridostigmine bromide (PB) may be added at low doses, increasing to the dose that produces the best response, not to exceed 360 mg daily. In children, equivalent doses of these medications will be given calculated on a surface area basis. The doses of DAP and PB will be periodically adjusted to assure that the smallest effective doses are used.
Patients who achieve significant clinical benefit from DAP, as judged by the study PI and the patient, may continue taking DAP as long as the drug is available from the sponsor, and as long as they return for regular follow-up evaluations at the Duke MG Clinic. Patients who are unable to return for regular follow-up will be required to have their local physician obtain DAP for them from the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01765140
|Contact: Vern C. Juel, M.D.||email@example.com|
|United States, North Carolina|
|Duke University Hospital|
|Durham, North Carolina, United States, 27710|
|Contact: Vern C. Juel, M.D. 919-684-4044 firstname.lastname@example.org|
|Principal Investigator: Vern C. Juel, M.D.|
|Principal Investigator:||Vern C. Juel, M.D.||Duke University|