Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins
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|ClinicalTrials.gov Identifier: NCT01764451|
Recruitment Status : Completed
First Posted : January 9, 2013
Last Update Posted : April 11, 2016
|Condition or disease||Intervention/treatment||Phase|
|Cavernous Angioma, Familial Cerebral Cavernous Malformations Cerebral Cavernous Hemangioma||Drug: Simvastatin||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||12 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins|
|Study Start Date :||March 2012|
|Actual Primary Completion Date :||January 2016|
|Actual Study Completion Date :||January 2016|
20-40 mg tablet taken daily by mouth. Month 1: 20 mg; Months 2 and 3: 40 mg.
Other Name: Zocor
|No Intervention: No Treatment|
- Change in blood brain barrier permeability over three months for the treatment group compared to the control group. [ Time Frame: Baseline, Three Months ]We will measure the change in blood brain barrier permeability with dynamic contrast enhanced MRI from baseline to three months. We will compare the change in permeability for a group of CCM patients placed on statin medication (treatment group) with a group of CCM patients not on statin medication (control group).
- Correlation of physiologic permeability data with anatomic lesion data [ Time Frame: Baseline, Three months ]Use dynamic contrast-enhanced MRI to detect abnormalities in brain permeability in CCM patients and correlate with anatomic lesion information.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01764451
|United States, New Mexico|
|University of New Mexico Health Sciences Center|
|Albuquerque, New Mexico, United States, 87131|
|Principal Investigator:||Leslie A Morrison, MD||University of New Mexico|
|Principal Investigator:||Blaine Hart, MD||University of New Mexico|