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Long Term Follow up of Patients Who Were Treated With Extracorporeal Membrane Oxygenation for Pandemic Influenza A/H1N1 Induced Severe Respiratory Failure

This study has been completed.
Karolinska Institutet
Uppsala University Hospital
Information provided by (Responsible Party):
Bernhard Holzgraefe, Karolinska University Hospital Identifier:
First received: January 4, 2013
Last updated: November 20, 2013
Last verified: November 2013
Patients treated with Extracorporeal Membrane Oxygenation (ecmo) for severe respiratory or circulatory failure show severe long term disability due to impaired lung -, cerebral-, cognitive function and impaired quality of life. This study investigates the long term outcome of all patients who are still alive three years after ECMO treatment for severe respiratory failure during the H1N1 2009 pandemic at the Karolinska University Hospital.

Condition Intervention
Long Term Outcome
Radiation: CT scan
Behavioral: Cognitive function
Radiation: MRI

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional

Further study details as provided by Karolinska University Hospital:

Primary Outcome Measures:
  • Lung function [ Time Frame: 3 years after ecmo treatment ]

Enrollment: 7
Study Start Date: October 2012
Study Completion Date: October 2013
Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
ECMO survivors
CT scan of the chest of all ECMO survivors after 2009/2010 pandemics Tests for cognitive function MRI of the brain Lung function
Radiation: CT scan Behavioral: Cognitive function Radiation: MRI


Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
All patients who survived ECMO treatment due to infection with Influenza A/H1N1 2009 up to 3 years after discharge from hospital

Inclusion Criteria:

  • Survivors of ECMO treatment for influenza a/h1n1 pneumonia during 2009/2010 pandemics at the ECMO Center Karolinska

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01763060

Karolinska University Hospital
Stockholm, Sweden, 17176
Sponsors and Collaborators
Karolinska University Hospital
Karolinska Institutet
Uppsala University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Bernhard Holzgraefe, MD, Karolinska University Hospital Identifier: NCT01763060     History of Changes
Other Study ID Numbers: Dnr 2012/986-31/3
Long term outcome ( Other Identifier: Ehtical committee Stockholm )
Study First Received: January 4, 2013
Last Updated: November 20, 2013

Keywords provided by Karolinska University Hospital:
pandemics processed this record on May 23, 2017