Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01762917
Recruitment Status : Completed
First Posted : January 8, 2013
Last Update Posted : January 8, 2013
Information provided by (Responsible Party):
Joachim Saur, Universitätsmedizin Mannheim

Brief Summary:
Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).

Condition or disease
Chronic Obstructive Pulmonary Disease Bronchial Asthma Restrictive Pulmonary Disease

Study Type : Observational
Actual Enrollment : 45 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Influence of Bag Volume Variation in Inert Gas Rebreathing Pulmonary Blood Flow Measurements on the Reproducibility in Patients With Pulmonary Diseases
Study Start Date : September 2007
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Patients suffering from pulmonary obstruction
Patients suffering from pulmonary restriction
Pulmonary healthy controls

Primary Outcome Measures :
  1. pulmonary blood flow [ Time Frame: 1 day ]
    variation of serial pulmonary blood flow measurements

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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
inpatients and outpatients, internal medicine, university hospital

Inclusion Criteria:

  • ability to perform rebreathing maneuver

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01762917

University Hospital Mannheim
Mannheim, Germany
Sponsors and Collaborators
Universitätsmedizin Mannheim

Responsible Party: Joachim Saur, Principal Investigator, Universitätsmedizin Mannheim Identifier: NCT01762917     History of Changes
Other Study ID Numbers: IGR_Vbag_MA
First Posted: January 8, 2013    Key Record Dates
Last Update Posted: January 8, 2013
Last Verified: January 2013

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases
Bronchial Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases