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Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

This study has been completed.
Information provided by (Responsible Party):
Joachim Saur, University Hospital Mannheim Identifier:
First received: December 21, 2012
Last updated: January 7, 2013
Last verified: January 2013
Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).

Chronic Obstructive Pulmonary Disease Bronchial Asthma Restrictive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Influence of Bag Volume Variation in Inert Gas Rebreathing Pulmonary Blood Flow Measurements on the Reproducibility in Patients With Pulmonary Diseases

Further study details as provided by Joachim Saur, University Hospital Mannheim:

Primary Outcome Measures:
  • pulmonary blood flow [ Time Frame: 1 day ]
    variation of serial pulmonary blood flow measurements

Enrollment: 45
Study Start Date: September 2007
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Patients suffering from pulmonary obstruction
Patients suffering from pulmonary restriction
Pulmonary healthy controls


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
inpatients and outpatients, internal medicine, university hospital

Inclusion Criteria:

  • ability to perform rebreathing maneuver

Exclusion Criteria:

  Contacts and Locations
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Please refer to this study by its identifier: NCT01762917

University Hospital Mannheim
Mannheim, Germany
Sponsors and Collaborators
Universitätsmedizin Mannheim
  More Information

Responsible Party: Joachim Saur, Principal Investigator, University Hospital Mannheim Identifier: NCT01762917     History of Changes
Other Study ID Numbers: IGR_Vbag_MA
Study First Received: December 21, 2012
Last Updated: January 7, 2013

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases
Bronchial Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases processed this record on August 18, 2017