Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype (ObeDi)
|ClinicalTrials.gov Identifier: NCT01762683|
Recruitment Status : Unknown
Verified January 2013 by Centre Hospitalier Universitaire Dijon.
Recruitment status was: Recruiting
First Posted : January 8, 2013
Last Update Posted : January 8, 2013
|Condition or disease||Intervention/treatment|
|Pregnancy Complication||Other: Myometrium biopsy and blood samples|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Study of Role of Mononuclear Cells of Maternal Peripheric Blood in Human Myometrial Primar Cell Lines Differentiation Toward a Contratyl Phenotype: Influence of Preconceptional Obesity|
|Study Start Date :||April 2012|
|Estimated Primary Completion Date :||November 2013|
Other: Myometrium biopsy and blood samples
The biopsy of myometrium is specially realised for the study in surgical unit after the release of the child, in women with normal pregnancy but necessitating a caesarean.
The blood samples are realised, specially for the study, either during the medical exam before the ceasarean or specifically for the study.
- Measuring the expression level of markers (Gama actine, Desmine, Connexine-43, and Ocytocine receptor) by Westernblotting [ Time Frame: up to 2 months ]Demonstrate in vitro the capacity of a Il-1B stimulus to induce the differentiation of the myometrial cells toward a hyperplasia phenotype, and that the answer depends on whether this is cells from normal weight women or obese women before conception.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01762683
|Contact: Marc BARDOU, Pr||380-393-433 ext +33||Marc.Bardou@u-bourgogne.fr|
|Maternité du CHU de Dijon||Recruiting|
|Dijon, Bourgogne, France, 21000|
|Contact: Marc BARDOU, Pr 380-393-433 ext +33 email@example.com|
|Contact: Isabelle LE RAY, Md 380-393-223 ext +33 Isabelle.Le-Ray-Ferrieres@u-bourgogne.fr|
|Principal Investigator: Paul SAGOT, Pr|