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Khalifa Acute Effects

This study has been completed.
Information provided by (Responsible Party):
Andreas Sandner-Kiesling , MD, Medical University of Graz Identifier:
First received: January 4, 2013
Last updated: May 4, 2015
Last verified: May 2015
The primary hypothesis is that Khalifa's therapy has different acute effects in various organ systems i.e. proprioceptive, neuro-muscular, endogenous dopamine system, etc. These effects might indicate the pathway of the therapy.

Condition Intervention
Totally Ruptured Anterior Cruciate Ligament in the Knee Other: Khalifa Therapy

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Interdisciplinary Evaluation of Acute Effects From Khalifa's Therapy at Patients With Fully Ruptured Anterior Cruciate Ligament (ACL).

Resource links provided by NLM:

Further study details as provided by Andreas Sandner-Kiesling , MD, Medical University of Graz:

Primary Outcome Measures:
  • Laser Doppler-Flow [ Time Frame: 1 hour ]

  • NIRS [ Time Frame: 1 hour ]
    Near infrared spectroscopy, Oxygen saturation

  • IR Thermography [ Time Frame: 1 hour ]
    Infrared thermography, temperature

  • QST [ Time Frame: 1 hour ]
    Quantitative sensoric testing, pain

  • HRV [ Time Frame: 1 hour ]
    Heart rate variability, sympathicus/parasympathicus activation

  • EEG [ Time Frame: 1 hour ]
    Electroencephalogram, brain waves

  • Knee function [ Time Frame: 1 hour ]
    IKDC Score KT-1000 test Clinical / physical examination

  • SportsScience [ Time Frame: 2 hours ]
    Posturomed Motion capture proprioception muscle power range of motion

  • Blood [ Time Frame: 1 hour ]
    Catecholamines endorphins standard blood parameters

Secondary Outcome Measures:
  • Questionnaire [ Time Frame: 1 hour ]
    Different questions about pain, lifestyle, subjective parameters

Estimated Enrollment: 10
Study Start Date: December 2012
Study Completion Date: February 2014
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: K-Pat
Getting one time one hour of Khalifa's therapy for ACL injury treatment.
Other: Khalifa Therapy
One hour of Khalifa's therapy which is specially applied pressure to the skin.

Detailed Description:
According to our previous study that evaluated the efficacy of Khalifa's therapy the investigators have seen that the therapy has acute effects which resulted in better knee function and later even in better healing of the ACL injury. This study should clear exactly which effects and pathways are involved in the therapy from multiple (interdisciplinary) point of views. Therefore the investigators will measure parameters that might be associated with this special technique directly before and after the therapy.

Ages Eligible for Study:   18 Years to 49 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • totally ruptured ACL - MRI verified, 2 weeks old as a maximum
  • knee function: Any functional inhibition (stretching, bending or load)
  • BMI: 18-25
  • athletically active

Exclusion Criteria:

  • any surgical procedures at the injured knee at any previous time
  • any acute surgical indication
  • diabetes mellitus and/or high blood pressure
  • any permanent drug treatment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01762371

Sports Center of University Salzburg
Hallein, Salzburg, Austria, 5400
Sponsors and Collaborators
Medical University of Graz
Principal Investigator: Andreas Kastner, MD AKH Linz
Principal Investigator: Andreas Sandner, MD Med Uni Graz
  More Information

Responsible Party: Andreas Sandner-Kiesling , MD, Univ.Prof.Dr., Medical University of Graz Identifier: NCT01762371     History of Changes
Other Study ID Numbers: KhalSbg1
Study First Received: January 4, 2013
Last Updated: May 4, 2015

Keywords provided by Andreas Sandner-Kiesling , MD, Medical University of Graz:

Additional relevant MeSH terms:
Wounds and Injuries processed this record on September 19, 2017