AMH and Pregnancy Rate by Age During Stimulate In-Vitro Fertilization Protocol
The woman fertility decrease with the age and there is a closely link with the ovarian reserve, the number of available eggs in the ovaries. Therefore, it is important to evaluate the ovarian reserve with specific marker to have a better prediction of the response of the in vitro fertilization treatment and to have a better rate of pregnancy.
Until now, a lot of clinical criteria (age, duration of the infertility, number of antral follicles) and biological (FSH, Oestradiol, Inhibin B, EFFORT test, number of the eggs at the retrieval day) was suggested to help for the estimation of the ovarian reserve.
Since couple of years, the anti-müllerian hormone (AMH) is recognize to be one of the best ovarian reserve marker, it corresponding the number of antral follicles, it is more sensitive and predictive. Moreover, during the In-Vitro Fertilization, the anti-müllerian hormone can provide the weak responds at the stimulation and the reverse, the risk of excessive responds (hyperstimulation). To choose the gonadotropin doses to administrate (stimulation ovarian hormone) during an In-Vitro Fertilization protocol, we need to know the anti-müllerian hormone dosage. However, if the anti-müllerian hormone is recognize to evaluate the quantity of available eggs in the ovaries, his role to determine the quality of these eggs still discussed.
The goal of this study is to verify if the serum anti-müllerian hormone (blood) is a good indicator for the quality of the reserve ovarian evaluating the impact of anti-müllerian hormone rate on the pregnancy rate and implantation rate, during stimulate In-Vitro Fertilization protocol.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||AMH and Pregnancy Rate by Age During Stimulate In-Vitro Fertilization Protocol|
- Pregnancy rates [ Time Frame: 7 weeks ]Clinical pregnancy rates per cycle and per transfer
- Cumulative pregnancy rates [ Time Frame: 5 years ]Cumulative pregnancy rates including all frozen embryo transfer
- Number of eggs [ Time Frame: 4 weeks ]Number of eggs retrieve at the end of the stimulated in-vitro fertilization cycle
- Number of embryos [ Time Frame: 4 weeks ]Number of embryos obtain at the end of the stimulated in-vitro fertilization cycle
|Study Start Date:||December 2012|
|Estimated Study Completion Date:||December 2017|
|Estimated Primary Completion Date:||December 2017 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01762111
|Montreal, Quebec, Canada, H4P 2S4|
|Principal Investigator:||Jacques Kadoch, MD||OVO R & D|