Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization

This study has been completed.
Information provided by (Responsible Party):
OVO R & D Identifier:
First received: January 3, 2013
Last updated: July 24, 2015
Last verified: July 2015

Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic. Sometimes, patient with chronic endometritis can have genital bleeding, pelvic chronic pain, pain during sexual relations, persistent vaginal white loosing. The hysteroscopy can detect the presence or absence of chronic endometritis.

Some studies showed that the endometritis could have an impact on the embryo implantation and could explain recurrent miscarriages or repeated embryo implantation failures.

The goal of this study is to evaluate the frequency of the chronic endometritis in patients with recurrent miscarriages or repeated embryo implantation failures

Abortion, Spontaneous

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Prevalence of Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization

Resource links provided by NLM:

Further study details as provided by OVO R & D:

Primary Outcome Measures:
  • Rate of chronic endometritis [ Time Frame: 1 day ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Pregnancy rate [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Enrollment: 100
Study Start Date: November 2012
Study Completion Date: May 2015
Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Recurrent miscarriages
Repeated embryo implantation failures


Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Population with recurrent miscarriage or repeated embryo implantation failures.

Inclusion Criteria:

Group repeated miscarriages

  • Women aged 18 to 43 years
  • ≥ 2 miscarriages before 14 weeks of gestation
  • Genetic (karyotype x2), thrombophilic and endocrine assessment should be completed

Group of implantation failure in In-vitro fertilization

  • Women aged 18 to 45 years
  • Absence of pregnancy after 3 good quality embryos transferred in women under 35 years and 4 embryos in the 35 years and over.

Exclusion Criteria:

  • Positive pregnancy test
  • Unexplained bleeding
  • Incomplete miscarriage assessment
  • Uterine malformation
  • Antibiotic treatment during or within one month prior to the biopsy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01762098

Canada, Quebec
Clinique Ovo
Montreal, Quebec, Canada, H4P 2S4
Sponsors and Collaborators
Principal Investigator: Pierre-Emmanuel Bouet, MD Université de Montréal
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: OVO R & D Identifier: NCT01762098     History of Changes
Other Study ID Numbers: OVO-12-20 
Study First Received: January 3, 2013
Last Updated: July 24, 2015
Health Authority: Canada: Health Canada

Keywords provided by OVO R & D:
In vitro fertilization
Endometrial biopsy

Additional relevant MeSH terms:
Abortion, Habitual
Abortion, Spontaneous
Adnexal Diseases
Genital Diseases, Female
Pelvic Inflammatory Disease
Pregnancy Complications
Uterine Diseases processed this record on May 30, 2016