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Does Deficiency in Vitamin D Induced Hypercoagulation or Thrombin Generation

This study has been completed.
Information provided by (Responsible Party):
Elias mazen, HaEmek Medical Center, Israel Identifier:
First received: December 4, 2012
Last updated: November 2, 2016
Last verified: December 2014

Working hypothesis and aims: The aim of our study is to investigate whether vitamin D deficiency could cause increased thrombin generation and a hypercoagulable state healthy volunteers.


In total 400 healthy volunteers are planned for inclusion in this trial. After signing an informed consent two blood samples will be obtained from each participant.

Expected results: invastigator expect to find that volunteers with vitamin D deficiency will have thrombin generation curve compatible with hypercoagulable state and returning to normal after treatment with vitamin D

Condition Intervention
Cardiovascular Disease Drug: Vitamin D

Study Type: Observational [Patient Registry]
Study Design: Time Perspective: Prospective
Target Follow-Up Duration: 3 Months

Resource links provided by NLM:

Further study details as provided by Elias mazen, HaEmek Medical Center, Israel:

Primary Outcome Measures:
  • the correlation between vitamin D levels and endogenous thrombin potential [ Time Frame: 3 month ]
    one blood test

Enrollment: 400
Study Start Date: April 2013
Study Completion Date: July 2013
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
healthy voulnters Drug: Vitamin D


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
400 healthy volunteers

Inclusion Criteria: age >18 healthy naive to drug treatment -

Exclusion Criteria:

no exc criteria

  Contacts and Locations
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Please refer to this study by its identifier: NCT01761669

Afula, Israel, 19101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Principal Investigator: mazen elias, MD Emek medical center
  More Information

Responsible Party: Elias mazen, Director of Internal Medicine C, HaEmek Medical Center, Israel Identifier: NCT01761669     History of Changes
Other Study ID Numbers: vitamin D
Study First Received: December 4, 2012
Last Updated: November 2, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Vitamin D
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on August 16, 2017