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Gauging Of Light Dependent Experiences Through Neuroimaging (GOLDEN) (GOLDEN)

This study has been completed.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by (Responsible Party):
University of Texas Southwestern Medical Center Identifier:
First received: January 2, 2013
Last updated: September 10, 2014
Last verified: September 2014
In the proposed study, the investigators will assess the brain's dopamine response to UVR light in individuals who use tanning beds both frequently and infrequently.

Condition Intervention
Compulsive and Infrequent Tanners
Device: Tanning

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Dopamine Response to Ultraviolet Light in Frequent and Infrequent Tanners

Resource links provided by NLM:

Further study details as provided by University of Texas Southwestern Medical Center:

Primary Outcome Measures:
  • Striatal dopaminergic efflux [ Time Frame: Up to one hour post-administration of UVR ]
    Determine if UVR induces striatal dopaminergic efflux is altered in compulsive tanners.

Secondary Outcome Measures:
  • Striatal D2 receptors [ Time Frame: 90 minutes prior to UVR administration ]
    Basal striatal D2 receptors will be assessed in infrequent and compulsive tanners.

Enrollment: 22
Study Start Date: January 2013
Study Completion Date: June 2014
Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Infrequent tanners
Individuals who tan less than twice a week and do not meet modified DSM-IV criteria for tanning addiction.
Device: Tanning
Participants will be placed under a tanning canopy for 4-10 minutes.
Compulsive Tanners
Individuals who tan more than 3 times per week in a tanning bed. Tanning must cause disruption in daily functioning. Must meet modified DSM-IV criteria for tanning addiction
Device: Tanning
Participants will be placed under a tanning canopy for 4-10 minutes.

Detailed Description:
UV radiation has recently been classified as a known human carcinogen by the US Department of Health and Human Services. Nevertheless, the voluntary exposure to sunlight continues unabated despite progressively increasing rates of ultraviolet radiation (UVR)-induced illness and death, particularly skin cancer. An increasingly common form of UVR administration is through the use of indoor tanning salons. Almost 30 million Americans, including 20% of 18-39 year olds, visit indoor tanning salons each year. Frequent and excessive tanning, despite a growing understanding by those who tan of the morbidity and mortality associated with tanning, suggests that UVR may impart rewarding effects beyond the assumed cosmetic benefits. Recent studies, in fact, have shown that up to 40% of both frequent beach and salon tanners exhibit signs and symptoms consistent with an addictive disorder, including an inability to decrease their tanning frequencies, compulsive tanning, and/or continued tanning despite adverse consequences. As the mesostriatal dopaminergic pathway plays a key role in reward and addiction, the investigators propose to extend this novel finding by directly assessing the mesostriatal dopaminergic reward pathway in compulsive and infrequent tanners. This pathway plays a key role in the experience and integration of reward and alterations in this system have been observed in addicted populations. Specifically, 1) striatal dopamine is released in response to rewarding substances and experiences, 2) striatal dopamine2/3 receptor densities are lower in cocaine, alcohol, opioid, and nicotine dependent, as well as obese, subjects, and 3) reward-induced striatal dopamine efflux has been shown to be decreased in addicted, relative to non-addicted, subjects.

Ages Eligible for Study:   21 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Subjects will be recruited though flyers and advertisements. Advertisements will be placed in college newspapers. Flyers will be placed on college campuses, and local Dallas stores and beauty salons.

Inclusion Criteria:

  • Between ages 21-40
  • Tan at least twice weekly over the last year (Frequent Tanners)
  • Tan less than twice a week over the last year (Infrequent Tanners)
  • Meet modified DSM-IV criteria for Frequent Tanners

Exclusion Criteria:

  • Medications that effect brain functioning
  • Other medical or psychiatric disorders that may affect neural functioning.
  • Drug and Alcohol abuse or dependence
  • Pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01761032

United States, Texas
UT Southwestern Medical Center at Dallas, Division on Addictions
Dallas, Texas, United States, 75390
Sponsors and Collaborators
University of Texas Southwestern Medical Center
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Principal Investigator: Bryon Adinoff, M.D. UT Southwestern Medical Center at Dallas
  More Information

Additional Information:
Responsible Party: University of Texas Southwestern Medical Center Identifier: NCT01761032     History of Changes
Other Study ID Numbers: STU 112011-012
R21AR063018 ( US NIH Grant/Contract Award Number )
Study First Received: January 2, 2013
Last Updated: September 10, 2014

Keywords provided by University of Texas Southwestern Medical Center:

Additional relevant MeSH terms:
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents processed this record on May 22, 2017