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Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40

This study has been completed.
Information provided by (Responsible Party):
Yonsei University Identifier:
First received: December 31, 2012
Last updated: February 17, 2014
Last verified: February 2014
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia. However, there have not been studies comparing the quality of recovery from the different methods of general anesthesia. In this study, the investigators compare the functional recovery after general anesthesia in TIVA and inhalation anesthesia with QoR-40 questionnaire.

Condition Intervention
Thyroid Operation Under General Anesthesia Drug: desflurane group Drug: TIVA group

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • QoR-40 score [ Time Frame: at 24 hours later after surgery ]
    QoR-40 score is going to be measured at preoperative period, 24 hours, and 48 hours later after surgery.

Enrollment: 76
Study Start Date: December 2012
Study Completion Date: January 2013
Primary Completion Date: January 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Desflurane group Drug: desflurane group
anesthesia is maintained with desflurane and remifentanil (Desflurane group)
Active Comparator: TIVA(total intravenous anesthesia) group Drug: TIVA group
anesthesia is maintained with fresofol and remifentanil (TIVA group).


Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients who are undergoing thyroid operation belong to ASA class 1 or 2

Exclusion Criteria:

  • patients who are belongs to ASA class 3 or more,
  • patients who have underlying complicated cardiovascular or psychological disease.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01760018

Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Yonsei University Identifier: NCT01760018     History of Changes
Other Study ID Numbers: 4-2012-0748
Study First Received: December 31, 2012
Last Updated: February 17, 2014

Keywords provided by Yonsei University:
desflurane, total intravenous anesthesia, QoR-40

Additional relevant MeSH terms:
Central Nervous System Depressants
Physiological Effects of Drugs
Analgesics, Opioid
Sensory System Agents
Peripheral Nervous System Agents
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Anesthetics, Inhalation processed this record on September 21, 2017