Evaluate the Effectiveness of Brain Network Activation (BNA™) Technology in the Management of Sport Related Concussion
Currently, there is no direct, reliable, bed-side, and non-invasive method for assessing changes in brain activity associated with concussion. Event Related Potentials (ERPs), which are temporal reflections of the neural mass electrical activity of cells in specific regions of the brain that occur in response to stimuli, may offer such a method, as they provide both a noninvasive and portable measure of brain function. The ERPs provide excellent temporal information, but spatial resolution for ERPs has traditionally been limited. However, by using high-density electroencephalograph (EEG) recording spatial resolution for ERPs is improved significantly. The paradigm for the current study will combine neurophysiological knowledge with mathematical signal processing and pattern recognition methods (BNA™) to temporally and spatially map brain function, connectivity and synchronization.
The proposed study will provide additional evidence for the utility and contribution of the BNA™ test (reflecting temporal and spatial changes in brain activity as well as brain functional connectivity associated with concussion) in concussion management.
Minor Traumatic Brain Injury (TBI)
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Evaluate the Effectiveness of Brain Network Activation (BNA™) Technology in the Management of Sport Related Concussion in the College Age Athletes|
- Changes in BNA™ measures during the sport season in both concussed and non concussed athletes compared to pre season BNA™ baseline measures. [ Time Frame: an average of 1 year ] [ Designated as safety issue: No ]
- Correlation of the BNA measures in both concussed and non concussed athletes to the clinical diagnosis. [ Time Frame: an average of 1 year ] [ Designated as safety issue: No ]
- To assess the clinical utility of changes in BNA in assisting with clinical decision-making. [ Time Frame: an average of 1 year ] [ Designated as safety issue: No ]
|Study Start Date:||September 2012|
|Study Completion Date:||December 2014|
|Primary Completion Date:||August 2014 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01759173
|Toronto, Ontario, Canada, M3J 1P3|
|Principal Investigator:||Mazyar Fallah, PhD||York University|