Association Between Inflammatory Activities and Gap Density
Recruitment status was Recruiting
The study aims to:
- To determine the relationship between inflammatory activities and epithelial gaps in IBD by CLE and evaluate epithelial gaps healing via dexamethasone treatment.
- To demonstrated the alteration of local barrier function in IBD using CLE.
Inflammatory Bowel Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Association Between Inflammatory Activities and Epithelial Gap Density in Inflammatory Bowel Disease|
- gap density [ Time Frame: 6 months ] [ Designated as safety issue: No ]the distributions of gap density
- local barrier function [ Time Frame: 6 months ] [ Designated as safety issue: No ]the comparison local barrier function between the IBD group and normal control patients
Biospecimen Retention: Samples With DNA
Observational Study Model: Case-Control
|Study Start Date:||December 2012|
|Estimated Study Completion Date:||June 2013|
|Estimated Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Inflammatory bowel disease
Patients previously diagnosed as having IBD
Asymptomatic individuals admitted for health surveillance or patients for follow up after polypectomy.
The primary end-point of this study was the cohort comparison of epithelial gap density and local barrier function as determined by CLE of subjects with IBD versus controls. Despite discontinuities in the cellular layer, the intestinal barrier function is maintained during this high cell turnover rate at the apical pole of the epithelial layer. Gaps first identified in vivo through acriflavine have pivotal definitions (lacked nuclei or cytosol, appeared to be filled with an impermeable substance). However, Current endoscopic technology does not identify whether there is material present in human gaps, so investigators could not formally resolve whether human epithelial gaps compromise or defend the epithelial barrier.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01758926
|Contact: Yanqing Li, MD, PhD||86-531-8216923 ext firstname.lastname@example.org|
|Department of Gastroenterology, Qilu Hospital, Shandong University||Recruiting|
|Jinan, Shandong, China, 250012|
|Contact: Yanqing Li, MD, PhD 86-531-82169236 ext 82169508 email@example.com|
|Study Director:||Yanqing Li, MD, PhD||Department of Gastroenterology, Qilu Hospital|