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Antipsychotic Discontinuation in High-risk Subjects

This study has been withdrawn prior to enrollment.
(administrative reason)
Information provided by (Responsible Party):
Jun Soo Kwon, Seoul National University Hospital Identifier:
First received: December 27, 2012
Last updated: October 12, 2016
Last verified: October 2016
  • Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control?
  • What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk subjects for psychosis?
  • What about the dopamine synthesis in recurred clinical high risk subjects for psychosis after the discontinuation?


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Antipsychotic Discontinuation in High-risk Subjects

Resource links provided by NLM:

Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • Presynaptic dopamine synthesis in the striatum [ Time Frame: baseline ]
    measured with [18F]DOPA positron emission tomography

Enrollment: 0
Study Start Date: December 2012
Estimated Study Completion Date: September 2016
Estimated Primary Completion Date: September 2016 (Final data collection date for primary outcome measure)
Healthy control
clinical high risk subjects for psychosis

Detailed Description:
After the antipsychotic medication discontinuation, we are going to assess the changes of the biological markers

Ages Eligible for Study:   16 Years to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Clinical high risk subjects for psychosis who have been treated with antipsychotic medication so that reach to the remission.

Inclusion Criteria:

  • Diagnosed as a clinical High Risk
  • Treated with antipsychotic drugs
  • PSP1-5 (from SIPS criteria) <3 (severity index)for more than 6 months
  • Had not experienced a symptomatic relapse in the 6 months

Exclusion Criteria:

  • Significant abnormality in laboratory tests
  • History of head trauma
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Please refer to this study by its identifier: NCT01758887

Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of, 110-744
Sponsors and Collaborators
Seoul National University Hospital
Principal Investigator: Jun Soo Kwon, MD PhD Seoul National University College of Medicine
  More Information

Responsible Party: Jun Soo Kwon, Professor, Seoul National University Hospital Identifier: NCT01758887     History of Changes
Other Study ID Numbers: H-1207-055-417
Study First Received: December 27, 2012
Last Updated: October 12, 2016
Individual Participant Data  
Plan to Share IPD: No

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Psychotropic Drugs processed this record on April 28, 2017