Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) (STRAIN)
Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load. This can be prevented by modifying ventilator settings, using vasopressors or inotropes or even by prone positionning.But to do so, right ventricular dysfonction has to be detected. Echocardiography has emerged as a first line tool to diagnose right heart failure. Recently, strain analysis showed promising results to detect early right ventricle abnormalities in other settings such as pulmonary hypertension or scleroderma. We therefore decided to determine whether 2D strain could help detect early right ventricular dysfunction in ARDS.
Acute Respiratory Distress Syndrome
Right Ventricular Dysfunction
Right Heart Failure
Acute Cor Pulmonale
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)|
- Right ventricle 2D strain [ Time Frame: Duration of mechanical ventilation ] [ Designated as safety issue: No ]We will assess whether 2D strain can detect a right ventricular dysfunction as compared to standard echocardiographic parameters
- Mean right ventricle strain under ventilated patients [ Time Frame: at inclusion ] [ Designated as safety issue: No ]We measure right ventricle strain (RV strain) in patients under mechanical ventilation for a non-respiratory cause. This allows us to determine the mean value of RV strain under ventilation when there is no respiratory failure.
- Reproducibility between transthoracic and transesophageal strain measures [ Time Frame: Time of mechanical ventilation ] [ Designated as safety issue: No ]In ARDS patients, we record a transthoracic and transesophageal echocardiography. We compare RV strain values obtained from transthoracic and transesophageal echocardiography.
- NT pro BNP and pre pro endothelin plasma level [ Time Frame: At inclusion in ARDS patients ] [ Designated as safety issue: No ]These assays are made based on the hypothesis they could help discriminate between patients who will develop a right ventricular dysfunction from those who will not. A blood sample is withdrawn at the same time as echocardiography only in the ARDS group.
Biospecimen Retention: Samples Without DNA
Plasmatic levels of NT proBNP and pre pro endothelin are monitored in ARDS group to determine whether these biomarkers can help detect right ventricular dysfunction.
|Study Start Date:||January 2013|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Patients under mechanical ventilation since less than 24 hours at inclusion and presenting acute respiratory distress syndrome criteria.
Patients under mechanical ventilation and presenting acute lung injury criteria.
Patients under mechanical ventilation for a non-respiratory cause
Please refer to this study by its ClinicalTrials.gov identifier: NCT01757522
|Contact: POTTON Leila, MD||33-476768779||LPotton@chu-grenoble.fr|
|University Hospital of Grenoble||Recruiting|
|Grenoble, Cedex 09, France, 38043|
|Contact: Leila POTTON, ACC 33-476768779 LPotton@chu-grenoble.fr|
|Contact: Caroline TOURNEGROS, CRA 33-476767109 CTournegros@chu-grenoble.fr|
|Principal Investigator: Leila POTTON, ACC|
|Sub-Investigator: Carole SCHWEBEL, PU/PH|
|Sub-Investigator: Agnes BONADONA, PH|
|Sub-Investigator: Rebecca HAMIDFAR, PH|
|Sub-Investigator: Clemence MINET, PH|
|Sub-Investigator: Claire ARA SOMOHANO, PH|
|Sub-Investigator: Maxime LUGOSI, ACC|
|Sub-Investigator: Patrice FAURE, PU/PH|
|Sub-Investigator: Bertrand TOUSSAINT, PU/PH|
|Sub-Investigator: Carole SAUNIER, PH|
|Principal Investigator:||Leila POTTON, ACC||University Hospital, Grenoble|