Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) (STRAIN)
|ClinicalTrials.gov Identifier: NCT01757522|
Recruitment Status : Unknown
Verified March 2016 by University Hospital, Grenoble.
Recruitment status was: Recruiting
First Posted : December 31, 2012
Last Update Posted : March 15, 2016
|Condition or disease|
|Acute Respiratory Distress Syndrome Right Ventricular Dysfunction Right Heart Failure Acute Cor Pulmonale|
|Study Type :||Observational|
|Estimated Enrollment :||290 participants|
|Official Title:||Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)|
|Study Start Date :||January 2013|
|Estimated Primary Completion Date :||December 2016|
|Estimated Study Completion Date :||December 2016|
Patients under mechanical ventilation since less than 24 hours at inclusion and presenting acute respiratory distress syndrome criteria.
Patients under mechanical ventilation and presenting acute lung injury criteria.
Patients under mechanical ventilation for a non-respiratory cause
- Right ventricle 2D strain [ Time Frame: Duration of mechanical ventilation ]We will assess whether 2D strain can detect a right ventricular dysfunction as compared to standard echocardiographic parameters
- Mean right ventricle strain under ventilated patients [ Time Frame: at inclusion ]We measure right ventricle strain (RV strain) in patients under mechanical ventilation for a non-respiratory cause. This allows us to determine the mean value of RV strain under ventilation when there is no respiratory failure.
- Reproducibility between transthoracic and transesophageal strain measures [ Time Frame: Time of mechanical ventilation ]In ARDS patients, we record a transthoracic and transesophageal echocardiography. We compare RV strain values obtained from transthoracic and transesophageal echocardiography.
- NT pro BNP and pre pro endothelin plasma level [ Time Frame: At inclusion in ARDS patients ]These assays are made based on the hypothesis they could help discriminate between patients who will develop a right ventricular dysfunction from those who will not. A blood sample is withdrawn at the same time as echocardiography only in the ARDS group.
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01757522
|Contact: Carole SCHWEBEL, PU/PHfirstname.lastname@example.org|
|University Hospital of Grenoble||Recruiting|
|Grenoble, Cedex 09, France, 38043|
|Contact: Carole SCHWEBEL, PU/PH 33-476768779 email@example.com|
|Contact: Cyrielle CLAPE, CRA 33-476767109 firstname.lastname@example.org|
|Principal Investigator: Carole SCHWEBEL, PU/PH|
|Sub-Investigator: Agnes BONADONA, PH|
|Sub-Investigator: Rebecca HAMIDFAR, PH|
|Sub-Investigator: Clemence MINET, PH|
|Sub-Investigator: Claire ARA SOMOHANO, PH|
|Sub-Investigator: Patrice FAURE, PU/PH|
|Sub-Investigator: Bertrand TOUSSAINT, PU/PH|
|Sub-Investigator: Carole SAUNIER, PH|
|Sub-Investigator: Nicolas TERZI, PU/PH|
|Principal Investigator:||Carole SCHWEBEL, PU/PH||University Hospital, Grenoble|