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Clinical Measures of Ovarian Reserve in Predicting IVF Success

This study has been completed.
Oxford Fertility Unit
Information provided by (Responsible Party):
University of Oxford Identifier:
First received: December 20, 2012
Last updated: May 10, 2016
Last verified: May 2016

The purpose of this study is to find out more about tests used to estimate the number of eggs a woman has remaining in her ovaries (her 'ovarian reserve'). It is thought that women who have a greater number of eggs or ovarian reserve may have a better chance of successful in vitro Fertilisation (IVF) treatment than those who have a smaller number of eggs. Accurately predicting the likely outcomes of IVF would be of great benefit for counselling patients before they go through expensive and demanding treatments such as IVF and IVF with Intracytoplasmic sperm injection (IVFICSI).

Over the past two decades, many endocrine and ultrasound markers have been designed and are now used as indicators of ovarian reserve. A number of screening tests are utilized to measure these markers, either by ultrasound scanning techniques or taking blood samples. However it is not yet known which, if any, best predict the outcome of IVF treatment. We would like to investigate these various measures of ovarian reserve to determine which are most accurate, particularly for predicting live birth rates, as up to now only poor to moderate quality evidence has been available for this outcome.

This will be a prospective cohort study of 300 women who already intend to undergo IVF/IVF-ICSI treatment. Study participants will have one extra blood sample and ultrasound examination, for the purposes of measuring markers of their ovarian reserve, at the start of their IVF/IVFICSI treatment cycle. No other interventions will be required and their treatment cycle will not be affected by their participation in the study.

Condition Intervention
Infertility, Female Procedure: Measurements of ovarian reserve

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Determining the Accuracy of Clinical Measures of Ovarian Reserve in Predicting Successful In Vitro Fertilisation (IVF)Treatment.

Resource links provided by NLM:

Further study details as provided by University of Oxford:

Primary Outcome Measures:
  • Live birth rate per cycle [ Time Frame: up to one year after last appointment of final participant ]

Enrollment: 204
Study Start Date: June 2012
Study Completion Date: June 2015
Primary Completion Date: June 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Ovarian reserve study participants
Measurements of ovarian reserve for women attending the Oxford Fertility Unit having their first IVF/IVF-ICSI cycle.
Procedure: Measurements of ovarian reserve
Blood test (AMH, E2, FSH) Ultrasound measurement of antral follicle count and ovarian volume


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Women attending the Oxford Fertility Unit planning an IVF/IVF-ICSI treatment cycle

Inclusion Criteria:

  • Participant is willing and able to give informed consent for participation in the study.
  • Female, aged 18 years or above.
  • First cycle of ovarian stimulation.
  • Suitable for standard 'long protocol' IVF/IVF-ICSI cycle.

Exclusion Criteria:

  • The participant does not understand the English language, or has special communication needs. This is because it is impractical to provide, for this small scale study, information sheets and consent forms in other languages except English.
  • Patients unsuitable for standard 'long protocol' IVF/IVFICSI cycle

    • Presence of endometrioma or any other kind of ovarian cyst > 20mm diameter.
    • Presence of Polycystic Ovarian Syndrome.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01756872

United Kingdom
Oxford Fertility Unit
Oxford, United Kingdom, OX4 2HW
Sponsors and Collaborators
University of Oxford
Oxford Fertility Unit
Principal Investigator: Tim Child University of Oxford
  More Information

Responsible Party: University of Oxford Identifier: NCT01756872     History of Changes
Other Study ID Numbers: NDOG-12/SC/0277
Study First Received: December 20, 2012
Last Updated: May 10, 2016

Keywords provided by University of Oxford:
Assisted reproductive technology
ovarian reserve

Additional relevant MeSH terms:
Infertility, Female
Genital Diseases, Male
Genital Diseases, Female processed this record on August 23, 2017