MRI in Portal Hypertension (MRQuee)
Recruitment status was: Recruiting
Death from chronic liver disease has doubled in the UK over the last decade. This is largely due to the rise in liver disease from excess alcohol consumption, obesity related fatty liver disease and hepatitis B & C infections. The current 'liver tests' only identify liver injury when the damage is at an advanced stage. They neither estimate the degree of injury accurately nor help judge prognosis. The complications from chronic liver disease result mainly from raised pressures within the liver. We currently measure this pressure by passing a long catheter through the jugular vein in the neck into the liver. This invasive test does carry a small yet significant risk of complications and is not available outside specialised liver centres. Raised pressure within the liver is also associated with changes in the microorganisms within the gut. This leads to increased infective complications among patients with liver cirrhosis.
We aim to noninvasively measure the pressures within the liver using Magnetic Resonance Imaging (MRI). We will recruit 49 patients with chronic liver disease who have had liver pressure measurements as part of their routine clinical assessment. The participants will attend the Biomedical Research Unit and the MR Centre for a single 2hour visit. We will also collect blood, urine and stool samples from them.
The diagnostic accuracy of the quantitative MRI techniques will be validated against the pressures obtained via the invasive test. The quantitative MRI techniques will also correlated with biomarkers of liver injury obtained from blood and urine samples. The stool sample obtained will be used to characterise the gut microorganisms in these patients.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Quantitative Magnetic Resonance Imaging (MRI) Techniques in the Evaluation and Estimation of Portal Hypertension|
- Diagnostic accuracy of quantitative MR techniques in the detection and grading the degree of portal hypertension compared to HVPG measurements. [ Time Frame: 18 months ]
- Correlation between quantitative MR techniques and serum biomarkers of fibrosis. [ Time Frame: 18 months ]
- Characterisation of the gut microbiota in patients with portal hypertension. [ Time Frame: 18 months ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||January 2013|
|Estimated Primary Completion Date:||June 2014 (Final data collection date for primary outcome measure)|
Patients with HVPG measurements
Patients having HVPG measurements for clinical reasons will be recruited to undergo research MRI scan.
|Procedure: MRI Scan|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01756859
|Royal Derby Hospitals|
|Derby, United Kingdom|
|Nottingham University Hospitals NHS Trust|
|Nottingham, United Kingdom, NG72UH|
|Principal Investigator:||Guruprasad Aithal||NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham|