Allergens in Inner-City Schools and Childhood Asthma (SICAS-1)
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
Asthma is a disease that affects more than 12% of Americans under the age of 18 for over 14 million missed school days per year, and is the number one cause of school absences in America. Elementary school children spend 6 to 10 hours a day in school, and most of that time is spent in one classroom. The goals of this project are to provide an understanding of exposure risk factors specific to the classroom. This is critical, because the classroom environment could potentially be considered as an effective target for prevention of inner-city asthma morbidity by reducing exposures to many symptomatic children through an intervention in the school classrooms.
Maximum Symptom Days/14 Days [ Time Frame: 14 days ]
Largest value among the following:
Number of days with wheezing, tightness in the chest, or cough Number of nights with disturbed sleep as a result of asthma Number of days on which the child had to slow down or discontinue play activities because of asthma
Secondary Outcome Measures
Days of Slowed Activity Due to Asthma [ Time Frame: 12 months ]
Days of Exercise-induced Symptoms [ Time Frame: 12 months ]
Days of Cough Without an Upper Respiratory Infection [ Time Frame: 12 months ]
Nights of Wakening Due to Asthma Symptoms [ Time Frame: 12 months ]
Number of Hospitalizations [ Time Frame: 12 months ]
Emergency Department Visits [ Time Frame: 12 months ]
Unscheduled Physician/Health Care Visits [ Time Frame: 12 months ]
Prednisone Bursts [ Time Frame: 12 months ]
FEV1/FVC [ Time Frame: 12 months ]
FEV1 Percent Predicted [ Time Frame: 12 months ]
Percent Change in FEV1 After Short-acting Beta Agonist [ Time Frame: 12 months ]
Exhaled Nitric Oxide Levels [ Time Frame: 12 months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
4 Years to 15 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
elementary school students with asthma
Grades K-8 the school year following spring recruitment (Ages 4-15)
Attend one of the schools in the fall where permission obtained for classroom sampling.
Able to provide assent and parent/guardian able to provide informed consent Physician-Diagnosed asthma AND Wheezing in the previous 12 months
Significant pulmonary diseases other than asthma that might influence test results or pose risks (e.g., cystic fibrosis, sarcoidosis, bronchiectasis)
Cardiovascular disease that requires daily medication
Taking a beta blocker
Unable to follow through with study visit or complete study procedures