Biological Monitoring of Nano Sized Particles in the Airways of Asthmatic Children (EHF)
Recruitment status was: Recruiting
Background Ambient airborne particulate material (PM) is defined according the aerodynamic diameter into coarse, fine, and ultrafine or "nano" sized particles ranging between 2.5-10 µm (coarse), <2.5 µm (fine), and <0.1 µm (nano(. Many studies have examined particle effect on respiratory health in children, mainly by environmental monitoring of coarse and fine particles. Biological assessment of individual exposure to nano sized particles in correlation to adverse health effect was not previously studied.
Hypothesis individual exposure to nano sized particles in children is associated with reduction in forced expiratory volume at one second.
|Study Design:||Observational Model: Ecologic or Community
Time Perspective: Prospective
|Official Title:||Biological Monitoring of Nano Sized Particles in the Airways of Asthmatic Children|
- spirometry values [ Time Frame: 1 sec ] [ Designated as safety issue: No ]forced expiratory volume at one second
- methacholine and adenosine challenge test results [ Time Frame: 1 sec ] [ Designated as safety issue: No ]provocative concentration causing a 20% fall in forced expiratory volume at one second and provocative dose causing a 20% fall in forced expiratory volume at one second
|Study Start Date:||July 2012|
|Estimated Study Completion Date:||June 2013|
|Estimated Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01754948
|Tel Aviv Medical Center|
|Tel Aviv, Israel|
|Study Director:||Shira Benor, MD||Tel Aviv Medical Center|