The Effect and Mechanism of Hyaluronan on the Mucociliary Differentiation of Human Respiratory Epithelial Cells

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2012 by Far Eastern Memorial Hospital.
Recruitment status was  Not yet recruiting
Information provided by:
Far Eastern Memorial Hospital Identifier:
First received: February 6, 2009
Last updated: December 20, 2012
Last verified: November 2012
The mucociliary system of nasal mucosa, which is composed of the ciliated respiratory epithelium, the mucous blanket, and the mucus-producing glands, is an important defense component of the respiratory system. Therefore, it is important to maintain intact inner respiratory mucociliary epithelium in reconstruction of large respiratory defect and in the development of tissue engineering trachea. Hyaluronan derivatives, which are biodegradable and non-immunogenic, have already proved to be effective as a scaffold for chondrocytes. However, the feasibility of use as a scaffold for respiratory epithelial cells remained unexplored. The aim of the study is to investigate the effect of hyaluronan including concentrations and molecular weight on the mucociliary differentiation of human respiratory epithelial cells (HREC). If hyaluronan is able to promote mucociliary differentiation of HREC, the investigators can synthesize hyaluronan derivatives serving as ideal biomaterials for respiratory tissue engineering and tissue-engineered trachea in the future.

Respiratory System Defect

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Effect and Mechanism of Hyaluronan on the Mucociliary Differentiation of Human Respiratory Epithelial Cells

Resource links provided by NLM:

Further study details as provided by Far Eastern Memorial Hospital:

Study Start Date: January 2009

Genders Eligible for Study:   Both
Sampling Method:   Non-Probability Sample
Study Population

Inclusion Criteria:

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  More Information

Responsible Party: Far Eastern Memorial Hospital-IRB Identifier: NCT01754584     History of Changes
Other Study ID Numbers: FEMH 97055 
Study First Received: February 6, 2009
Last Updated: December 20, 2012
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Far Eastern Memorial Hospital:
hyaluronan including concentrations
molecular weight
mucociliary differentiation
human respiratory epithelial cells

Additional relevant MeSH terms:
Hyaluronic Acid
Adjuvants, Immunologic
Immunologic Factors
Pharmacologic Actions
Physiological Effects of Drugs
Protective Agents
Viscosupplements processed this record on May 05, 2016