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NEAT! Technology to Increase Breaks in Sedentary Behavior in Adults With Diabetes

This study has been completed.
Information provided by (Responsible Party):
Christine Pellegrini, Northwestern University Identifier:
First received: December 13, 2012
Last updated: April 26, 2017
Last verified: April 2017
Sedentary behavior is associated with an increased risk of mortality and many health conditions including type 2 diabetes, obesity, cardiovascular disease, and metabolic syndrome, independent of the time spent in moderate-to-vigorous intensity physical activity (MVPA). Furthermore, independent of total sedentary time and MVPA, Healy et al. observed that individuals who had more breaks in sedentary time had lower 2-h plasma glucose. Recent experimental findings also suggests that breaking up prolonged bouts of sedentary behavior (≥ 20 minutes) with either light or moderate intensity activity for 2 minutes reduces postprandial glucose and insulin responses.10 Replacing sedentary time with light-intensity activity or nonexercise activity thermogenesis (NEAT) may help to reduce the health consequences of sedentary behavior. The purpose of this study is to develop a smartphone application (NEAT!) to encourage sedentary adults with diabetes to increase breaks in prolonged bouts of sedentary behavior objectively measured by an accelerometer. NEAT! will be refined by modifying technology created for the ENGAGED trial (RC1DK087126) and will work in conjunction with a Bluetooth enabled accelerometer that can detect bouts of sedentary behavior. When a sedentary bout (≥ 20 minutes) is detected, the smartphone application will trigger a reminder prompt to the user encouraging him/her to participate in NEAT for at least 2 minutes. Following the development, testing, and refining of the application, a sample of 10 sedentary adults with type 2 diabetes will be recruited to participate in a one month trial to examine the feasibility and acceptability of NEAT!. To our knowledge, this is the first study to design and examine the acceptability of a smartphone application that will target interrupting sedentary behavior with NEAT using objectively measured sedentary time in a diabetic population.

Condition Intervention
Diabetes Mellitus Behavioral: NEAT!

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Official Title: NEAT! Technology to Increase Breaks in Sedentary Behavior in Adults With Diabetes

Resource links provided by NLM:

Further study details as provided by Christine Pellegrini, Northwestern University:

Primary Outcome Measures:
  • Acceptability of NEAT! [ Time Frame: 1 month ]
    How many participants would continue to use or use NEAT! in the future

Secondary Outcome Measures:
  • Adherence to NEAT! [ Time Frame: 1 Month ]
    NEAT usage (days/month)

  • Breaks in Sedentary Behavior [ Time Frame: Baseline and 1 month ]
    Changes in the number of breaks in sedentary behavior will be assessed via accelerometry between baseline and 1 month

  • Changes in Total Sedentary Time [ Time Frame: Baseline and 1 month ]
    Changes in total sedentary behavior will be assessed via accelerometry between baseline and 1 month

Enrollment: 9
Study Start Date: February 2013
Study Completion Date: October 2013
Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: NEAT!
Participants will use the NEAT! smartphone application and accelerometer over a 1 month period.
Behavioral: NEAT!
Participants will wear the accelerometer and use the NEAT! application during waking hours for 1 month. The NEAT! app will prompt participants to stand up when they have been sitting for a prolonged period.


Ages Eligible for Study:   21 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 21-70 years of age
  • have physician diagnosed type 2 diabetes that is currently being treated by dietary modification, oral agents, or insulin
  • currently and plan on having an Android smartphone for the next 2 months
  • be willing to wear an accelerometer and use the NEAT! application
  • spend the majority of the day sitting.

Exclusion Criteria:

  • unable to ambulate without assistance
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01754467

United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
Northwestern University
Principal Investigator: Christine Pellegrini, Ph.D. Northwestern University
  More Information

Responsible Party: Christine Pellegrini, Research Assistant Professor, Northwestern University Identifier: NCT01754467     History of Changes
Other Study ID Numbers: CCDTR01
Study First Received: December 13, 2012
Results First Received: January 25, 2017
Last Updated: April 26, 2017

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases processed this record on September 20, 2017