Assessing the Prevalence of Metabolic Syndrome in Renal Transplantation
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|ClinicalTrials.gov Identifier: NCT01753973|
Recruitment Status : Completed
First Posted : December 20, 2012
Last Update Posted : December 16, 2015
|Condition or disease|
|Chronic Renal Failure (CRF) Renal Transplantation|
Metabolic syndrome ( MS) is characterized by the presence of a number of metabolic and hemodynamic disorders such as hypertension (HBP ) , abdominal obesity , dyslipidemia, abnormal glucose metabolism and insulin resistance , resulting in increased cardiovascular morbidity and mortality and the risk for developing type 2 diabetes mellitus.
The concept of metabolic syndrome (MS ) was first described by Reaven in 1988 as a combination of obesity , dyslipidemia , hypertension and fasting hyperglycemia , insulin resistance and inflammation as common pathophysiological disorders in cardiovascular disease (CVD). But the first comprehensive definition of MS was established only in 1998 , the World Health Organization ( WHO ) , in order to facilitate research in this area and points as a key indicator of SM the presence of hyperglycemia and / or resistance to insulin associated with days or more metabolic abnormalities (hypertension, dyslipidemia , obesity, and microalbuminuria).
In the general population , the presence of MS is associated with increased risk of developing diabetes mellitus ( DM ) and cardiovascular disease . Some studies have associated the SM to the appearance of proteinuria and reduction in the value of the glomerular filtration rate ( GFR ), suggesting an association SM with chronic kidney disease ( CKD ) .
Metabolic syndrome (MS) consists of complex disorder that involves assembly cardiovascular risk factors related to abdominal fat deposition and insulin resistance . MS is associated with cardiovascular disease , increasing overall mortality by about 1.5 times and cardiovascular mortality by about 2.5 times.
In 2001 , the National Cholesterol Education Program - Panel of the National Cholesterol Education Program ( NCEP - ATP III ), prepared another proposal. According to the NCEP ATP III, SM represents the combination of at least three components.
|Study Type :||Observational|
|Actual Enrollment :||200 participants|
|Official Title:||Assessing the Prevalence of Metabolic Syndrome in Renal Transplantation|
|Study Start Date :||January 2013|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2015|
- To evaluate the prevalence of metabolic syndrome in renal transplant patients. [ Time Frame: 12 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01753973
|Hospital das Clinicas - Faculdade de Medicina da Universidade de São Paulo|
|Sao Paulo, Brazil, 05403-900|
|Principal Investigator:||Elias David-Neto, MD||University of Sao Paulo|
|Principal Investigator:||Fabiana Agena, MS||University of Sao Paulo|