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Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01752868
First Posted: December 19, 2012
Last Update Posted: December 19, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Barnes-Jewish Hospital
Information provided by (Responsible Party):
Washington University School of Medicine
  Purpose
The purpose of this study is to determine if a combination of 10 nutritional supplements provide health benefits that are consistent with protection against age-related disease. All supplements have been shown in previous studies to have health benefits when administered alone. The hypothesis is that 6 months of taking 10 nutritional supplements each day will provide beneficial changes in healthy related measures.

Condition Intervention
Healthy Volunteers Dietary Supplement: Supplement

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

Resource links provided by NLM:


Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • Carotid-femoral pulse wave velocity [ Time Frame: Baseline and 6 months ]

Enrollment: 56
Study Start Date: May 2011
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: supplement Dietary Supplement: Supplement
Participants in this group will take the following nutritional supplements on a daily basis: curcumin, fish oil, resveratrol, sesamin, Acetyl-L-carnitine, lipoic acid, green and black teas, quercetin, pomegranate, cinnamon bark.
No Intervention: control

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age 40-60 yr
  • body mass index of 21 - 30 kg/m2
  • sedentary to moderately active
  • eating a typical US diet

Exclusion Criteria:

  • history of any chronic disease other than mild osteoarthritis
  • use of medications other than occasional use of non-steroidal anti-inflammatory drugs, antihistamines, antacids or laxatives
  • use of nutritional supplements
  • smoking
  • alcohol intake greater than two drinks per day for women and three drinks per day for men
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01752868


Locations
United States, Missouri
Washington University Medical Center
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Barnes-Jewish Hospital
Investigators
Principal Investigator: Luigi Fontana, MD, PhD Washington University School of Medicine
  More Information

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT01752868     History of Changes
Other Study ID Numbers: BJH 6936-33
First Submitted: December 14, 2012
First Posted: December 19, 2012
Last Update Posted: December 19, 2012
Last Verified: December 2012