Sleep Restriction and Energy Expenditure
|ClinicalTrials.gov Identifier: NCT01751581|
Recruitment Status : Completed
First Posted : December 18, 2012
Last Update Posted : August 2, 2013
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Behavioral: Short Sleep Behavioral: Habitual sleep||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||10 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||The Effect of Sleep Reduction on Daily Energy Expenditure, Thermic Effect of Food, and Substrate Oxidation in Overweight Women|
|Study Start Date :||November 2011|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||April 2013|
Active Comparator: Habitual Sleep
Women sleep 8 h/night throughout the study phase
Behavioral: Habitual sleep
Participants sleep 8 h/night throughout the study phase (from 11 pm to 7 am)
Experimental: Short Sleep
Women sleep 4 h/night throughout the study phase
Behavioral: Short Sleep
Participants will be restricted in sleep and only allowed to sleep from 1 am to 5 am.
- Resting Metabolic Rate [ Time Frame: 32 hours ]Metabolic rate from 11 pm on day 2 until 7 am on the morning of day 4 will be measured in a metabolic chamber. The metabolic chamber is an air-tight room (22,000 l volume) equipped with a bed, chair, desk, television, VCR, telephone, treadmill, sink and toilet. All meals and snacks will be served at the scheduled time. Subjects will be asked to perform 30 min of light physical activity at 1500 h and 2030 h. Physical activity will consist of 30 min of cycling at 12 mi/h. Bedtimes will be the same as the previous night and actigraph monitoring will be used to confirm compliance with the sleep protocol. Women will exit the chamber at 0700 h the following day.
- Post Prandial Energy Expenditure and Thermic Effect of Food [ Time Frame: 8 hours on day 4 ]
Energy expenditure will be measured from 8 am until approximately 2:30 pm on day. Resting metabolic rate over 45 minutes will be measured at 8 am, followed by breakfast and resumption of energy expenditure measurements postprandially.
Participants will be given 15 min to consume a high-fat breakfast (50% of energy from fat) and post-prandial thermogenesis and substrate oxidation will be measured for the next 6 h.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01751581
|United States, New York|
|St. Luke's Hospital|
|New York, New York, United States, 10026|
|Principal Investigator:||Marie-Pierre St. Onge, PhD||St. Luke's Roosevelt Hospital/Columbia University|