Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A (CCA1)
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ClinicalTrials.gov Identifier: NCT01750710 |
Recruitment Status :
Completed
First Posted : December 17, 2012
Last Update Posted : October 9, 2019
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Condition or disease |
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Charcot-Marie-Tooth Type 1A Neuropathy |
Study Type : | Observational |
Actual Enrollment : | 37 participants |
Observational Model: | Other |
Time Perspective: | Cross-Sectional |
Official Title: | Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A |
Actual Study Start Date : | December 2012 |
Actual Primary Completion Date : | April 28, 2016 |
Actual Study Completion Date : | April 28, 2016 |

- axonal loss [ Time Frame: at day 1 ]
- Muscle strength [ Time Frame: at day 1 ]
- Functional scores [ Time Frame: at day 1 ]
- Hand testing [ Time Frame: at day 1 ]
- spatial and temporal parameters of walking [ Time Frame: at day 1 ]
- Barometric stabilometric podo-static scores [ Time Frame: at day 1 ]
- Quality of life [ Time Frame: at day 1 ]
- Fatigue [ Time Frame: at day 1 ]
- Depression [ Time Frame: at day 1 ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Patients older than 18 years
- Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2)
- Listening and written French
- Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome.
- Strength of the quadriceps superior to 2/5 MMT MRC
Exclusion Criteria:
- Presence of other neurological comorbidity
- Presence of coronary artery disease unstabilized
- Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy.
- Gait trouble of other origin
- Patients unable to give their consent.
- Intellectual deficit that does not allow to comply with tests

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01750710
France | |
CHU Clermont-Ferrand | |
Clermont-Ferrand, France, 63003 |
Principal Investigator: | Emmanuel COUDEYRE | University Hospital, Clermont-Ferrand |
Responsible Party: | University Hospital, Clermont-Ferrand |
ClinicalTrials.gov Identifier: | NCT01750710 |
Other Study ID Numbers: |
CHU-0128 |
First Posted: | December 17, 2012 Key Record Dates |
Last Update Posted: | October 9, 2019 |
Last Verified: | October 2019 |
Charcot-Marie-Tooth disease type 1A neuropathy Isokinetic Electromyography Walking |
Tooth Diseases Peripheral Nervous System Diseases Charcot-Marie-Tooth Disease Nerve Compression Syndromes Hereditary Sensory and Motor Neuropathy Neuromuscular Diseases Nervous System Diseases |
Stomatognathic Diseases Nervous System Malformations Heredodegenerative Disorders, Nervous System Neurodegenerative Diseases Polyneuropathies Congenital Abnormalities Genetic Diseases, Inborn |