Subcapsular Orchiectomy in Men With Klinefelter Syndrome
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ClinicalTrials.gov Identifier: NCT01750632 |
Recruitment Status
:
Completed
First Posted
: December 17, 2012
Last Update Posted
: October 4, 2016
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Condition or disease | Intervention/treatment | Phase |
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Klinefelter Syndrome | Procedure: Orchiectomy | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 14 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Treatment |
Study Start Date : | August 2010 |
Actual Primary Completion Date : | February 2014 |
Actual Study Completion Date : | December 2014 |

Arm | Intervention/treatment |
---|---|
Experimental: Orchiectomy
The patients undergo subcapsular orchiectomy
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Procedure: Orchiectomy
The patients undergo subcapsular orchiectomy with basic surgical instruments. The patients are given local analgesia and sometimes universal anesthesia.
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- Presence of testicular sperm [ Time Frame: Between 1 and 6 months ]
- Clinical pregnancy rate after ICSI with retrieved testicular sperm [ Time Frame: participants will be followed for the duration of fertility treatment, an expected average of 6 months ]
- Predictive value of FSH and other hormones for the presence of testicular sperm [ Time Frame: Between 1 and 6 months ]

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Ages Eligible for Study: | 15 Years to 40 Years (Child, Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Klinefelter
- 15-40 years of age
Exclusion Criteria:
- inability to understand the study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01750632
Denmark | |
Fertility Clinic, Odense University Hospital | |
Odense, Denmark, 5000 |
Publications of Results:
Responsible Party: | Jens Fedder, Professor, Consultant, Ph.D., Odense University Hospital |
ClinicalTrials.gov Identifier: | NCT01750632 History of Changes |
Other Study ID Numbers: |
Lab.Reprod.Biol.-Horsens-02 M-20100041 |
First Posted: | December 17, 2012 Key Record Dates |
Last Update Posted: | October 4, 2016 |
Last Verified: | October 2016 |
Additional relevant MeSH terms:
Syndrome Klinefelter Syndrome Disease Pathologic Processes Sex Chromosome Disorders of Sex Development Disorders of Sex Development Urogenital Abnormalities |
Sex Chromosome Disorders Chromosome Disorders Congenital Abnormalities Genetic Diseases, Inborn Gonadal Disorders Endocrine System Diseases Hypogonadism |