Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity
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ClinicalTrials.gov Identifier: NCT01750333
Verified December 2012 by Monica Montagnani, Montagnani, Monica, M.D., Ph.D.. Recruitment status was: Active, not recruiting
The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity
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Ages Eligible for Study:
5 Years to 13 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
CHILDREN ATTENDING THE OUTPATIENT UNIT OF THE UNIVERSITY PEDIATRIC CLINIC
Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.
presence of renal, liver and/or cardiovascular diseases;
metabolic and/or endocrine disorders;
histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study