Validation of Pulse Wave Doppler Demodulation Algorithm for the Continuous, Non-invasive Measurement of Blood Flow Velocity
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|ClinicalTrials.gov Identifier: NCT01750125|
Recruitment Status : Completed
First Posted : December 17, 2012
Last Update Posted : May 1, 2014
|Condition or disease||Intervention/treatment|
|Focus is on Healthy Subjects||Device: measure ascending aortic blood flow with pulse wave Doppler|
Currently there is no commercially available mechanism for the measurement of blood flow velocity waveforms non-invasively. Blood flow velocity waveforms require the use of invasive catheters, thus precluding clinical use. Such information would allow the researcher / practitioner the ability to continuously measure blood flow, pulse pressure, and the pulsatility index of any vascular structure accessible by ultrasound with minimal additional risk to the subject / patient. This data, when combined with arterial blood pressure data, could also be used to measure peripheral pressure volume loops as well as aortic vascular impedance, both of which cannot be currently measured in vivo.
The ability to measure blood flow velocity waveforms at high temporal resolution would provide clinicians with new tools for hemodynamic optimization (both a novel means of estimating myocardial oxygen consumption [pressure volume area] as well as afterload [aortic vascular impedance]) and researchers with the ability to conduct hemodynamic experiments that were not previously possible. This work will serve as the foundation for several other related projects which depend on the ability to continuously record blood flow velocity waveforms.
|Study Type :||Observational|
|Actual Enrollment :||10 participants|
|Study Start Date :||December 2012|
|Primary Completion Date :||January 2013|
|Study Completion Date :||January 2013|
In these health subjects we will measure ascending aortic blood flow with pulse wave Doppler and also record the raw audio of the Doppler signal
|Device: measure ascending aortic blood flow with pulse wave Doppler|
- Comparison between estimated arterial flow waveform and pulse wave Doppler trace [ Time Frame: day of procedure ]Estimated arterial flow waveform using fast Fourier transformation (FFT) will be compared to the pulse wave Doppler trace from the device
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01750125
|United States, Virginia|
|University of Virginia|
|Charlottesville, Virginia, United States, 22908|