Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse
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|ClinicalTrials.gov Identifier: NCT01749696|
Recruitment Status : Completed
First Posted : December 17, 2012
Last Update Posted : May 9, 2014
|Condition or disease|
|Pelvic Organ Prolapse|
The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.
The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Official Title:||Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse.|
|Study Start Date :||November 2009|
|Actual Primary Completion Date :||September 2012|
|Actual Study Completion Date :||April 2014|
Patients with pelvic organ prolapse
Patients, who were operated on because of pelvic organ prolapse.
Patients without pelvic organ prolapse
Patients, who had hysterectomy due to other reasons than pelvic organ prolapse.
- The elastin content in tissue samples in patients with or without pelvic organ prolapse. [ Time Frame: september 2012 ]
- The collagen content in tissue samples in women with or without pelvic organ prolapse. [ Time Frame: September 2012 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01749696
|Department of Obstetrics and Gynecology, Turku University Central Hospital|
|Turku, Finland, 20520|