Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Effect of Short-term Oxygen During CPET in Pulmonary Hypertension (ExOx-CPET)

This study has been completed.
Information provided by (Responsible Party):
University of Zurich Identifier:
First received: October 4, 2012
Last updated: August 11, 2016
Last verified: August 2016
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.

Condition Intervention Phase
Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
Chronic Cardiorespiratory Disease
Procedure: Supplemental oxygen via a mask
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise Capacity in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Watt [ Time Frame: 1 day ]
  • exercise time [ Time Frame: 1 day ]

Secondary Outcome Measures:
  • Peak oxygen uptake [ Time Frame: 1 day ]
  • Respiratory exchange ratio [ Time Frame: 1 day ]
  • ventilatory equivalent of carbon dioxide (VE/VCO2) slope [ Time Frame: 1 day ]
  • end-tidal pressures of carbon dioxide (PET CO2) [ Time Frame: 1 day ]
  • Changes in arterial blood parameters [ Time Frame: 1 day ]

Enrollment: 20
Study Start Date: December 2012
Study Completion Date: July 2016
Primary Completion Date: March 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Supplemental oxygen
Supplemental oxygen will be applied via a mask during CPET
Procedure: Supplemental oxygen via a mask
Placebo Comparator: Sham room air
Room air will be applied similarly to oxygen
Procedure: Supplemental oxygen via a mask


Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  • diagnosis of pulmonary arterial hypertension class I and IV (according to the latest WHO classification scheme of Dana Point 2008)
  • on optimized medical therapy and in stable condition for at least 4 week
  • desaturate in the 6 minute walking test by at least 4% to values <92%

Exclusion criteria:

  • unstable conditions
  • pregnant women
  • patients with pulmonary venous hypertension
  • patients with relevant concomitant lung disease and severe daytime hypoxemia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01748474

University Hospital Zurich, Division of Pneumology
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
Principal Investigator: Silvia Ulrich Somaini, MD University Hospital Zurich, Division of Pneumology
  More Information

Responsible Party: University of Zurich Identifier: NCT01748474     History of Changes
Other Study ID Numbers: KEK-ZH-NR. 2012-0251
Study First Received: October 4, 2012
Last Updated: August 11, 2016

Additional relevant MeSH terms:
Hypertension, Pulmonary
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases processed this record on April 27, 2017