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Short-term Cognitive Training in Late-life Depression

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ClinicalTrials.gov Identifier: NCT01748032
Recruitment Status : Terminated (Low Recruitment)
First Posted : December 12, 2012
Last Update Posted : April 7, 2016
Sponsor:
Collaborator:
Baycrest
Information provided by (Responsible Party):
Linda Mah, MD, Rotman Research Institute at Baycrest

Brief Summary:

The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD).

The hypotheses are:

  1. post-training cognitive performance will be superior to pre-training cognitive performance
  2. post-training depressive symptomatology will be less severe as compared with pre-training clinical severity and
  3. AUT group will show better post-training cognitive performance and improved mood symptoms when compared with the WAT group.

Condition or disease Intervention/treatment Phase
Depression Behavioral: Cognitive training Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: The Effects of Short-term Cognitive Training on Cognition and Mood Symptoms in Late-life Depression: A Pilot Study
Study Start Date : August 2012
Actual Primary Completion Date : June 2014
Actual Study Completion Date : September 2014

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Alternative Uses Training
In this task, subjects are asked to produce atypical and alternative uses for common daily objects.
Behavioral: Cognitive training
20 minutes/day for 5 sequential working days
Other Name: cognitive intervention
Word Association Training
In this task, subjects are asked to generate the first word that comes to their mind, and thus, encourages more general and spontaneous divergent thinking.
Behavioral: Cognitive training
20 minutes/day for 5 sequential working days
Other Name: cognitive intervention



Primary Outcome Measures :
  1. Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed [ Time Frame: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day ]

    Computerized Executive Tasks:

    • Number-Letter Task
    • Letter-Memory Task
    • Stroop Task

    Non-Computerized Measures:

    • Cattell Culture Fair Intelligence Test
    • Mattis Dementia Rating Scale-2 (DRS-2)


Secondary Outcome Measures :
  1. Changes in mood including depression, anxiety and apathy [ Time Frame: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day ]
    • Montgomery Asberg Depression Rating Scale (MADRS)
    • Apathy Evaluation Scale (AES)
    • Hamilton Anxiety Rating Scale (Ham-A)
    • Beck Depression Inventory (BDI)



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Ages Eligible for Study:   55 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male or female
  • Age >=55
  • Proficiency in English
  • Current depressive episode and meet criteria for DSM-IV major depressive disorder
  • Hamilton Depression Rating Scale score >=15
  • Able to give informed consent
  • Stable medication dosages during the training period

Exclusion Criteria:

  • Other DSM-IV Axis I psychiatric disorders, except for anxiety disorders due to high comorbidity with mood disorders
  • Mini-Mental State Examination score of <26
  • Diagnosis of dementia
  • Neurological and medical conditions known to affect cognition (e.g., stroke, head injury, previous chemotherapy for cancer)
  • Unstable medical illnesses requiring active treatment
  • Vision or hearing impairment affecting ability to participate in training

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01748032


Locations
Canada, Ontario
Rotman Research Institute at Baycrest
Toronto, Ontario, Canada, M6A 2E1
Sponsors and Collaborators
Rotman Research Institute at Baycrest
Baycrest
Investigators
Principal Investigator: Linda Mah, MD, M.H.Sc. Rotman Research Institute at Baycrest

Responsible Party: Linda Mah, MD, Clinician Scientist, Rotman Research Institute at Baycrest
ClinicalTrials.gov Identifier: NCT01748032     History of Changes
Other Study ID Numbers: 12-28
First Posted: December 12, 2012    Key Record Dates
Last Update Posted: April 7, 2016
Last Verified: April 2016

Keywords provided by Linda Mah, MD, Rotman Research Institute at Baycrest:
depression
intervention studies

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders