Myocardial Performance at Rest and During Exercise in Heart Failure With Preserved Ejection Fraction (X-HF-SPECKLE)
This study is being done to study how well the heart contracts and relaxes during exercise. In addition to traditional measures of heart function, we will use a new computer program that may improve understanding of why people feel shortness of breath or fatigue.
Patients at Risk of Heart Failure
Other: Cardiac rehabilitation
Other: Myocardial deformation imaging
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Myocardial Performance at Rest and During Exercise in Heart Failure With Preserved Ejection Fraction: Speckle Tracking Echocardiography - One Piece of the Puzzle.|
- Myocardial deformation [ Time Frame: Throughout single visit (less than 1 hour) for healthy controls; 1 hour sessions before and after exercise training (3 months apart) for patients at risk of heart failure. ] [ Designated as safety issue: No ]Myocardial deformation imaging (e.g. strain, strain rate, torsion) requires clear 2-dimensional echocardiography images that will be obtain at rest and during mild and moderate intensity exercise. Images will be captured during 6-10 minute bouts of exercise on a tilting exercise table. Comparisons will be made on resting and exercise values between groups. Our hypothesis is that strain rate will not increase in patients at risk of heart failure demonstrating lack of cardiovascular reserve.
- Stroke volume [ Time Frame: Throughout each testing session ] [ Designated as safety issue: No ]Stroke volume can be measured by combined Doppler and 2-dimensional echocardiography. A surrogate measure of stroke volume (oxygen-pulse) can also be obtained during cardiopulmonary exercise testing by dividing the measured oxygen consumption by the heart rate. Our hypothesis is that stroke volume will plateau early after exercise onset in patients at risk of heart failure and this plateau will correlate with a reduction in strain rate.
- Physiological adaptation to clinical exercise [ Time Frame: Immediately after cardiac rehabilitation completion (Patients with heart failure only); one session, lasting 1 hour, following 3 months of cardiac rehabilitation. ] [ Designated as safety issue: No ]Aerobic exercise training has been shown to improve hemodynamics and quality of life in patients at risk of heart failure. Our hypothesis is that the improvement in aerobic capacity following cardiac rehabilitation will correlate with an improvement in myocardial deformation imaging, specifically strain rate.
|Study Start Date:||June 2012|
|Estimated Study Completion Date:||February 2016|
|Estimated Primary Completion Date:||February 2016 (Final data collection date for primary outcome measure)|
Individuals without history of cardiovascular disease and at least 18 years of age.
|Other: Myocardial deformation imaging|
Patients at risk of heart failure
Individuals at risk of heart failure and an ejection fraction of at least 50%.
|Other: Cardiac rehabilitation Other: Myocardial deformation imaging|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01747785
|Contact: Mary Hagen, R.N.||507-538-1281|
|United States, Wisconsin|
|Mayo Clinic Health System - Franciscan Healthcare||Recruiting|
|La Crosse, Wisconsin, United States, 54601|
|Contact: Terry Pedace 608-392-9462|