Results at 10 to 14 Years After Microfracture in the Knee

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01747681
Recruitment Status : Completed
First Posted : December 12, 2012
Last Update Posted : January 27, 2015
Information provided by (Responsible Party):
Bergen Orthopedic Study Group

Brief Summary:
Articular cartilage lesions are commonly occurring. In a prospective study of 1,000 knee arthroscopies focal chondral or osteochondral defects were found in 19% of the patients (Hjelle 2002). Chronic articular cartilage defects do not heal spontaneously. However, acute traumatic osteochondral lesions or surgically inflicted lesions extending into subchondral bone, e.g. by drilling (Pridie 1959), spongialization, abrasion or microfracture with an angled awl (Rodrigo 1994) causing the release of pluripotent mesenchymal stem cells from the bone marrow, may heal with repair tissue consisting of fibrous tissue, fibrocartilage or hyaline-like cartilage. The microfracture technique causes little damage to the subchondral bone plate and the risk of heat necroses caused by drilling or abrasion is eliminated. The quality of the repair tissue after these bone marrow stimulating techniques depends on various factors including the species and age of the individual, the size and localization of the defect, the surgical technique, e.g., how the subchondral bone plate is treated, and the postoperative rehabilitation protocol. Microfracture has been used in small traumatic defects in young sporting individuals (Steadman 2003) as well as in larger osteoarthritic lesions in older patients (Miller 2004, Steadman 2007). The purpose of the present study was to investigate the long-term clinical outcome 10 to 14 years after microfracture of articular cartilage defects in the knee and possible predictors of good and poor outcomes.

Condition or disease Intervention/treatment
Articular Chondral Defect Procedure: Microfracture

Study Type : Observational
Actual Enrollment : 110 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Results at 10 to 14 Years After Microfracture in Articular Cartilage Defects in the Knee
Study Start Date : December 2012
Actual Primary Completion Date : December 2013
Actual Study Completion Date : February 2014

Group/Cohort Intervention/treatment
Microfracture of articular chondral defect
Procedure: Microfracture

Primary Outcome Measures :
  1. Lysholm knee score [ Time Frame: 10 to 14 years after surgery (in 2012-2013) ]
    All patients operated with a microfracture chondroplasty in the knee in 1999-2002 are invited to complete a patient-administered Lysholm score form

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All patients operated with a microfracture of articular chondral defects in the knee at the Deaconess University Hospital from 1999 to 2002.

Inclusion Criteria:

  • Patients with symptomatic focal full-thickness chondral lesions verified by arthroscopic examination and a minimum of 10-year follow-up.

Exclusion Criteria:

  • Exclusion criteria were joint space narrowing (< 4 mm) on standard antero-posterior x-ray films,
  • axial malpositioning,
  • ligament instabilities or inability to follow the rehabilitation protocol.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01747681

Deaconess University Hospital, Haraldsplass
Bergen, Hordaland, Norway, 5009
Sponsors and Collaborators
Bergen Orthopedic Study Group
Study Director: Eirik Eirik, MD, PhD Professor

Publications of Results:
Responsible Party: Bergen Orthopedic Study Group Identifier: NCT01747681     History of Changes
Other Study ID Numbers: 2012-Microfracture
First Posted: December 12, 2012    Key Record Dates
Last Update Posted: January 27, 2015
Last Verified: January 2015

Keywords provided by Bergen Orthopedic Study Group:
chondral defect
cartilage repair
outcome study
Lysholm score

Additional relevant MeSH terms:
Fractures, Stress
Fractures, Bone
Wounds and Injuries